Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

By A. Hirasawa, K. Tsumaya, T. Awaji, S. Katsuma, T. Adachi, M. Yamada, Y. Sugimoto, S. Miyazaki, G. Tsujimoto. Nature Medicine, 2005

1,527 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/09db4d3d7a0faf53871dac6173b3203c26d27ae5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. P. Calder
2. Josephine M. Egan
3. Wook Kim
4. M. Nauck
5. D. J. Drucker
6. F. Reimann
7. Jerrold M. Olefsky
8. F. Gribble

In Molecular Biology

1. P. Calder
2. J. Tschopp
3. Rongbin Zhou
4. M. Nauck
5. Greta Guarda
6. Aubry Tardivel
7. Wei Jiang
8. Zhigang Tian

In Surgery

1. M. Nauck
2. Josephine M. Egan
3. Wook Kim
4. D. J. Drucker
5. J. Tschopp
6. K. Honda
7. F. Reimann
8. B. Kahn

Citations in the corpus

• The Microbiome in Infectious Disease and Inflammation (2012, positive): “GPR120 is expressed not only in IECs, but also in numerous other cells, including adipocytes, DCs, and macrophages (119).”
• Glucagon-like peptide 1 (GLP-1) (2019, background): “Dose-dependent fatty acid-induced GLP-1 secretion is evident with a-linolenic acid (C18:3), docosahexanoic acid (C22:6), and palmitoleic acid (C16:1), oleic acid (C18:1), stearic acid (C18:0), and octanoic acid (C8:0) [251] are less”
• Free Fatty Acid Receptors in Health and Disease. (2020, neutral): “C20:3n-3/eicosatrienoic acid 11 (35) 1 (117)”
• Mammalian G proteins and their cell type specific functions. (2005, background): “Another recently deorphanized GPCR probably coupled to Gq/G11 is GPR120, which was suggested to be involved in fatty acid-induced release of GLP-1 from intestinal cells, thereby contributing to GLP-1-mediated insulin release (265).”
• Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects (2014, methodology): “Bioactive lipids can influence biology through binding to cell surface receptors such as G protein-coupled receptors (GPCRs) (Hara et al., 2013).”
• INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE (2012, neutral): “There is a family of lipid sensing GPCRs, including GPR40, 41, 43, 84, and 120 (Itoh et al., 2003; Tazoe et al., 2008; Wang et al., 2006), and recent reports have indicated that omega 3 FAs can stimulate GPR120 (Hirasawa et al., 2005; Oh et al., 2010).”
• The Role of Incretins in Glucose Homeostasis and Diabetes Treatment (2008, background): “In addition, treatment with p38 MAPK inhibitor leads to an increase in insulin transcription in the presence of either GLP-1 or Ex-4 and this effect is mediated via the CRE site (Kemp and Habener, 2001).”
• GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. (2010, positive): “Long-chain FAs can activate GPR40 (Itoh et al., 2003) and GPR120 (Hirasawa et al., 2005).”
• Diet, metabolites, and "western-lifestyle" inflammatory diseases. (2014, neutral): “GPR120 (Hirasawa et al., 2005; Ichimura et al., 2012; Oh et al., 2010), GPR84 (Suzuki et al.”