Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

By T. Means, E. Latz, F. Hayashi, M. Murali, D. Golenbock, A. Luster. Journal of Clinical Investigation, 2005

908 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/09cf94cdb9b87c9641ac74fe3c79f1163113001f

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In Immunology

Citations in the corpus

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus (2011, background): “S Neutrophil antimicrobial peptides protect DNA from nuclease degradation Previous studies have shown that autoantibodies in immune complexes can interact with FcgRII on pDCs and trigger receptor-mediated endocytosis of self-DNA (19, 21).”
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement (2005, background): “Recent studies have shown that chromatin-containing ICs can induce cytokine production by murine BM-derived DCs through a mechanism involving FcRIII and TLR9 (4, 5).”
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. (2006, background): “Indeed, a role for TLRs in stimulating dendritic cells (DCs) in autoimmune disease was suggested by the finding that DCs secrete inflammatory cytokines via a TLR9- or TLR7-dependent mechanism upon stimulation with nucleic acid-containing immune complexes (Boule et al., 2004; Means et al., 2005; Sa”
Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview (2017, background): “Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3.”
Plasmacytoid Dendritic Cells: Recent Progress and Open Questions (2011, background): “These complexes may be delivered into the endosomal compartment of pDCs via Fc receptor FcγRII (138, 140), and their stimulatory capacity can be augmented by the nuclear DNA-binding protein HMGB1 (141).”
DAMPening Inflammation by Modulating TLR Signalling (2010, background): “Autoantibodies against dsDNA and nucleosomes from SLE patients induce DC activation through TLR2 if bound to HMGB1 [89, 90].”
Pattern recognition receptors and inflammation. (2010, background): “Furthermore, nucleic acids bound to autoantibodies are endocytosed through B cell receptors and FcgRIIA in B cells and DCs (Means et al., 2005; Viglianti et al., 2003).”
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “In patients with SLE, pDCs are continuously activated by circulating immune complexes comprising self DNA and antibodies to DNA or nucleoprotein”
Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8 (2009, background): “…systemic lupus erythematosus (SLE), selfRNA and self-DNA are complexed with autoantibodies against the nucleic acid or nucleoproteins, which deliver the nucleic acids into endosomal compartments of pDCs via FcRII-mediated endocytosis (Rönnblom et al., 2003; Barrat et al., 2005; Means et al., 2005).”