The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila

By S. Pantalacci, N. Tapon, P. Léopold. Nature Cell Biology, 2003

596 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/09c14a96c7c98a308cd37b5891b166033305484a

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In Cell Biology

1. K. Guan
2. Bin Zhao
3. Duojia Pan
4. G. Halder
5. Fa-Xing Yu
6. Randy L. Johnson
7. Xaralabos Varelas
8. Yonggang Zheng

In Molecular Biology

1. K. Guan
2. Duojia Pan
3. Bin Zhao
4. G. Halder
5. Randy L. Johnson
6. Fa-Xing Yu
7. Xaralabos Varelas
8. Yonggang Zheng

In Oncology

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2. Bin Zhao
3. Duojia Pan
4. Randy L. Johnson
5. G. Halder
6. Xaralabos Varelas
7. Fa-Xing Yu

Citations in the corpus

• Hippo signaling in organ size control. (2007, background): “…next major advance in the genesis of the Hpo pathway was the identification of the Hpo tumor suppressor gene (Harvey et al. 2003; Jia et al. 2003; Pantalacci et al. 2003; Udan et al. 2003; Wu et al. 2003), which encodes a Ste-20 family protein kinase with a similar loss-of-function overgrowth…”
• The Hippo signaling pathway in stem cell biology and cancer (2014, unknown): “In Drosophila, the core components of the Hippo pathway include the kinase cascade of Ste20-like kinase Hpo (Hippo) and NDR family kinase Wts (Warts) [1–7].”
• The Hippo Signaling Pathway in Development and Disease (2019, background): “, 2002), hippo (hpo) (Harvey et al., 2003; Jia et al., 2003; Pantalacci et al., 2003; Udan et al., 2003; Wu et al., 2003), and mob as tumor suppressor (mats) (Lai et al.”
• The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. (2008, background): “Loss-of-function mutations in the hpo pathway components including hpo, sav, and wts resulted in similar tissue overgrowth phenotypes (Harvey et al., 2003; Jia et al., 2003; Pantalacci et al., 2003; Tapon et al., 2002; Udan et al., 2003; Wu et al., 2003).”
• The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. (2010, background): “sav (shar-pei) encoding a WW domain-containing protein and hippo (hpo) encoding a STE20 family protein kinase are two other Hippo pathway components identified in a similar fashion to that of wts (Kango-Singh et al. 2002; Tapon et al. 2002; Harvey et al. 2003; Jia et al. 2003; Pantalacci et al. 2003”
• The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. (2005, background): “Studies from several groups, including our own, have suggested that these genes function in a common pathway that coordinately regulates cell proliferation and apoptosis by targeting the cell-cycle regulator CycE and the celldeath inhibitor DIAP1 (Tapon et al., 2002; Kango-Singh et al., 2002; Harvey”
• Hippo signaling: growth control and beyond (2011, background): “…et al., 2008; Harvey et al., 2003; Huang et al., 2005; Jia et al., 2003; Kango-Singh et al., 2002; Neto-Silva et al., 2010; Nolo et al., 2006; Pantalacci et al., 2003; Peng et al., 2009; Tapon et al., 2002; Thompson and Cohen, 2006; Udan et al., 2003; Wu et al., 2003; Wu et al., 2008; Zhang…”
• Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. (2005, background): “Moreover, Hpo directly phosphorylates an apoptosis inhibitor DIAP1 and may regulate DIAP1 levels through degradation (Harvey et al., 2003; Pantalacci et al., 2003).”
• Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (2007, background): “Hippo (Hpo) is a Ste20 family protein kinase that complexes with a regulatory scaffold protein Salvador (Sav) (Kango-Singh et al. 2002; Tapon et al. 2002; Harvey et al. 2003; Pantalacci et al. 2003; Udan et al. 2003; Wu et al. 2003).”
• The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “The Hippo pathway was identified in genetic studies of Drosophila melanogaster as a suppressor of tissue overgrowth (Huang et al., 2005; Jia et al., 2003; Justice et al., 1995; Pantalacci et al., 2003; Tapon et al., 2002; Udan et al., 2003; Wu et al., 2003).”
• Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. (2011, background): “…mutation of the Hippo pathway genes or transgenic expression of Yki, the YAP homolog, results in enlarged organ size (Kango-Singh et al. 2002; Tapon et al. 2002; Harvey et al. 2003; Jia et al. 2003; Pantalacci et al. 2003; Udan et al. 2003; Wu et al. 2003; Huang et al. 2005; Lai et al. 2005).”
• Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. (2012, background): “The Hippo pathway is a newly established tumor suppressor pathway that limits organ size under physiological conditions (Justice et al. 1995; Xu et al. 1995; Kango-Singh et al. 2002; Tapon et al. 2002; Harvey et al. 2003; Jia et al. 2003; Pantalacci et al. 2003; Udan et al. 2003; Wu et al. 2003; Hua”
• The Hippo Signaling Pathway in Development and Cancer (2010, background): “…Kango-Singh et al., 2002), the Ste20like protein kinase Hippo (Hpo) (Wu et al., 2003; Udan et al., 2003; Harvey et al., 2003; Jia et al., 2003; Pantalacci et al., 2003) and the adaptor protein Mob-as-tumor-suppressor (Mats) (Lai et al., 2005), were discovered in genetic screens in Drosophila…”