Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice

By M. Saito, T. Iwawaki, C. Taya, H. Yonekawa, M. Noda, Y. Inui, E. Mekada, Y. Kimata, A. Tsuru, K. Kohno. 2001

515 citations recorded by the source corpus.

Subfields: Biotechnology, Immunology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Eric G. Pamer
2. Steffen Jung
3. B. Malissen
4. Dan R. Littman
5. R. Lang
6. F. Geissmann
7. M. Guilliams
8. TA Wynn

In Molecular Biology

1. Roger C. Wiggins
2. S. Tajbakhsh
3. Dan R. Littman
4. Eric G. Pamer
5. Steffen Jung
6. David J. Anderson
7. A. Basbaum

Citations in the corpus

• Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration (2011, background): “It is possible that DT might bind to mouse receptors, albeit with a significantly lower affinity than to the human DTR (Saito et al., 2001); therefore, at high doses, an additional non-specific effect of DT cannot be excluded.”
• In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. (2002, methodology): “A similar conditional ablation strategy was recently used toResults study hepatocyte function (Saito et al., 2001).”
• Hilar Mossy Cell Degeneration Causes Transient Dentate Granule Cell Hyperexcitability and Impaired Pattern Separation (2012, unknown): “We also generated loxP-flanked diphtheria toxin receptor (fDTR) transgenic mouse lines under the control of a CaMKIIa promoter, in which the human homolog of heparin-binding epidermal growth factor-like growth factor (HB-EGF) functions as a DTR in mice (Saito et al., 2001).”
• Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. (2005, background): “This results in inhibition of protein synthesis, leading to cell death (22,23).”
• Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli (2009, methodology): “To determine the behavioral consequences of ablating Mrgprd neurons, we used a conditional strategy (18, 19), in which the human diphtheria toxin receptor (DTR) was inserted in the Mrgprd locus (Fig.”