NF-kappaB in cancer: from innocent bystander to major culprit.

By M. Karin, Yixue Cao, F. Greten, Zhi-wei Li. Nature Reviews. Cancer, 2002

1,162 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/09b2ff252e249227ad4555102691368388e1827d

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Citations in the corpus

Molecular mechanisms of drug resistance (2005, background): “NF-κB has been connected with multiple pathways involved in oncogenesis, including cell cycle regulation and apoptosis [243,244].”
Integrative genomic approaches identify IKBKE as a breast cancer oncogene. (2007, background): “…signaling pathway including IKBKB, CARD11, MALT1, and BCL10 are required for the survival and proliferation of specific diffuse large B cell lymphoma cell lines (Ngo et al., 2006), the mechanism responsible for increased NF-kB activity in human breast tumors remained undefined (Karin et al., 2002).”
IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis (2003, background): “Furthermore, given that NFkB plays a central role in tumor promotion (75), we can now add HIF-1α to the growing list of tumor-promoting signaling molecules in its repertoire.”
Cell Death Pathways in Photodynamic Therapy of Cancer (2011, background): “NF-B dimers are held in the cytoplasm through specific inhibitors of kappa B, the IBs [81].”
Persistently-activated Stat3 maintains constitutive NF-κB activity in tumors (2009, unknown): “NF-kB consists of five Rel-related proteins, and the prototypical NF-kB complex is a RelA/p50 heterodimer, which is important for NF-kB-mediated antiapoptotic effects (Karin et al., 2002).”
Reactive oxygen species in tumor progression. (2005, background): “implicated in the development of leukemia and lymphoma, which are both caused by uncontrolled proliferation of blood cells, as well as the development of cancers of epithelial origin (carcinomas) such as breast carcinoma, or gastric and colorectal carcinoma (reviewed in (152, 156)).”
Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems (2017, background): “NF-κβ plays a central role in the regulation of apoptosis, oncogenesis and inflammation and is associated with cancer when over-expressed [97].”
The Role of Metallothionein in Oxidative Stress (2013, background): “Overexpression of NF-κB renders cancer cells resistant to chemotherapeutic agents [128,129], and it has been suggested that the antiapoptotic proteins IAP, IEX-1L and the Bcl-2 family are regulated by NF-κB transcription [130–132].”
NF‐κB and the link between inflammation and cancer (2012, background): “Considering these findings, together with observing activated NF-jB in a large number of cancers, most of which are not associated with genetic alterations in NF-jB, IKK, or upstream components within the signaling system, we proposed that NF-jB may provide a critical mechanistic link between inflam”
Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “Constitutive NF-κB activation often observed in cancer cells may be promoted by either microenvironmental signals, including cytokines, hypoxia and Reactive Oxygen Intermediates (ROI), or by genetic alterations [18].”
Cyclin D1, Cancer Progression and Opportunities in Cancer Treatment (2016, background): “Other related studies implicated c-Rel, RelB, and p52 in the regulation of cyclin D1 transcription in mammary tumors of transgenic mice [28], suggesting a key role of NF-κB-dependent regulation of cyclin D1 during mammary gland tumorigenesis.”
The NF-κB pathway (2005, background): “Since NF- B also regulates the expression of a variety of proteins that inhibit apoptosis and promote cell survival/proliferation, it is also implicated in carcinogenesis (Karin et al., 2002).”