Integrative genomic approaches identify IKBKE as a breast cancer oncogene.

By J. Boehm, Jean J. Zhao, Jun Yao, S. Kim, R. Firestein, I. Dunn, Sarah K. Sjostrom, Levi A. Garraway, S. Weremowicz, A. Richardson and 16 more. Cell, 2007

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How researchers see this paper

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Inflammation meets cancer, with NF-κB as the matchmaker (2011, background): “In addition, the IKK-like kinase IKKe has been identified as a contributor to the malignant activity of breast carcinoma cell”
Oncogene addiction. (2008, background): “the survival of breast cancer cells in which it is overexpressed, thus providing another example of oncogene addiction (19).”
Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival (2008, background): “Importantly, very recent study by Hahn and collaborators demonstrated that, even though both activated B-Raf and MEK1 could promote anchorage independent growth of human cells, only activated MEK1 could support tumor formation in nude mice (122).”
NF-κB, an Active Player in Human Cancers (2014, neutral): “IKK1, IKK2, and IKK ε mutations have been reported in genomic sequencing studies of breast and prostate cancers (8-10); however, a direct link of these mutations and constitutive NF-κ B activation in tumor cells has not been well established.”
NF‐κB and the link between inflammation and cancer (2012, background): “IKKe), can play NF-jB-independent roles in a variety of cancers that involve nuclear targets (16, 17).”
Network-based global inference of human disease genes (2008, background): “IKBKE, ranked at 793, is identiﬁed by integrative genomic approaches as a breast cancer oncogene (Boehm et al , 2007).”