Derivation of hepatocytes from bone marrow cells in mice after radiation‐induced myeloablation

By N. Theise, S. Badve, R. Saxena, O. Henegariu, S. Sell, J. M. Crawford, D. Krause. Hepatology, 2000

990 citations recorded by the source corpus.

Subfields: Genetics, Hepatology, Oncology

View Paper: https://www.semanticscholar.org/paper/0976ef40cce2285441ec6b50f3fb3f938763f881

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Fred H. Gage
2. Stuart H. Orkin
3. D. Anderson
4. N. Fausto
5. S. Sell
6. Irving L. Weissman
7. Austin G Smith
8. Daniel J. Garry

In Hepatology

1. N. Fausto
2. G. Michalopoulos

In Oncology

1. S. Sell
2. Irving L. Weissman
3. Fred H. Gage

Citations in the corpus

• Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. (2002, background): “For instance, cells infused at the time of bone marrow (BM) transplantation contribute to skeletal muscle myoblasts [1,2] and endothelium [3–7] and acquire hepatic [8-10], biliary duct [8-10], lung, gut, skin epithelia [11], and neuroectoderm [12,13].”
• Stem cell origin of cancer and differentiation therapy. (2004, background): “Given the finding that hepatocytes can arise from bone marrow precursors [160–163], it seems likely that circulating bone marrow-derived stem cells that enter the liver will do so in the periductular region, via the hepatic artery or the portal vein.”
• Diversification of haematopoietic stem cells to specific lineages (2000, background): “Even more recently the contribution of purified HSCs to hepatic oval cells, possible hepatocyte precursors, and to hepatocytes in the mouse has also been documente”
• Bone marrow cells regenerate infarcted myocardium (2001, background): “However, this limitation in stem cell differentiation potential has been challenged by studies showing that bone marrow and neural stem cells can produce many cell type”
• Stem cell plasticity: time for a reappraisal? (2005, positive): “Additional evidence of a BM-derived hepatic SC came from Theise et al.47 who also used a gender mismatch BM transplantation strategy to track donor-derived SC in the liver of lethally irradiated mice.”
• Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential (2004, background): “…throughout the organism’s life, their progeny giving rise to a variety of tissues derived from other embryonic germ layers (Ferrari et al., 1998; Kopen et al., 1999; Asahara et al., 1999; Theise et al., 2000; Brazelton et al., 2000; Krause et al., 2001; Orlic et al., 2001; Mezey et al., 2003).”