The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

By E. Batlle, E. Sancho, C. Francı́, David Domı́nguez, M. Monfar, J. Baulida, A. G. Herreros. Nature Cell Biology, 2000

2,754 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/095ff22fc2cbfb79a6a92bccd7e139cf75431f18

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Weinberg
2. M. Nieto
3. Jing Yang
4. J. P. Thiery
5. Thomas Brabletz
6. A. Cano
7. Zena Werb
8. Youhua Liu

Citations in the corpus

• The epithelial-mesenchymal transition generates cells with properties of stem cells. (2008, background): “…traits, we induced an EMT in nontumorigenic, immortalized human mammaryepithelial cells (HMLEs) by ectopic expression of either the Twist or Snail transcription factors, both of which are capable of inducing EMTs in epithelial cells (Batlle et al., 2000; Cano et al., 2000; Yang et al., 2004, 2006).”
• Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail (2003, methodology): “To examine the effects of the Snail expression on epithelial morphology in cultured cells, dog MDCK II cells or human HT29M6 cells have previously been used (Cano et al., 2000; Batlle et al., 2000).”
• A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. (2008, methodology): “…765 The generation of colon HT-29 M6, SW-480, and LS-174T, or pancreatic RWP-1 cell populations transfected with Snail1 has been reported elsewhere (Batlle et al. 2000; Peiró et al. 2006; G. Solanas, C. Agustí, M. Porta-de-la-Riva, D. Casagolda, F. Sánchez-Aguilera, F. Pons, S. Peiró, M. Escrivà,…”
• Epithelial–mesenchymal transition in development and cancer: role of phosphatidylinositol 3′ kinase/AKT pathways (2005, background): “The overproduction of Snail or Slug induces EMT in vitro (Batlle et al., 2000).”
• Epithelial-mesenchymal transitions in development and disease. (2009, background): “…sequences in the E-cadherin promoter with the help of local modifications of chromatin structure after the recruitment of SIN3A, histone deacetylases HDAC1 and HDAC2, and components of the Polycomb 2 complex (Cano et al., 2000; Batlle et al., 2000; Fraga et al., 2004; Herranz et al., 2008).”
• Dynamic EMT: a multi‐tool for tumor progression (2021, neutral): “…to repress epithelial genes like the E-cadherin encoding gene CDH1 via binding to E-Box motifs in their cognate promoter regions (Nieto et al , 2016) as shown for SNAIL (Batlle et al , 2000; Cano et al , 2000), TWIST (Yang et al , 2004), ZEB1 (Eger et al , 2005), and ZEB2 (Comijn et al , 2001).”
• Cadherin switching (2008, background): “E-cadherin is expressed by most normal epithelial tissues and many epithelium-derived cancer cells have lost E-cadherin expression (Batlle et al., 2000; Cano et al., 2000; Comijn et al., 2001; Nieman et al., 1999; Wheelock et al., 2001).”
• The Snail genes as inducers of cell movement and survival: implications in development and cancer (2005, background): “4 summarises those that are involved in processes in which Snail genes: repress epithelial markers (Cano et al., 2000; Batlle et al., 2000; Guaita et al., 2002; Ikenouchi et al., 2003; Tripathi et al., 2005a); upregulate mesenchymal markers (Cano et al., 2000; Guaita et al., 2002); or participate…”
• The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors (2003, background): “The human promoter contains three E-boxes at –79, –30 and +22 nt position (Hennig et al., 1995; Giroldi et al., 1997; Batlle et al., 2000), the mouse promoter contains two adjacent E-boxes at –86 and –80, inside the E-pal element, and the proximal E-box at –31, but lacks the downstream E-box at +22…”
• The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition (2001, background): “Our data show that, as was found in cultured cells and in metastatic carcinomas (3, 7), the E-cadherin gene is a target for repression by the Sna protein.”
• Epithelial-mesenchymal plasticity in cancer progression and metastasis (2019, background): “SNAI1 and SNAI2 bind to E box sequences in the promoter region of CDH1 and directly repress its transcription by recruiting the polycomb repressive complex (Batlle et al., 2000; Cano et al., 2000; Herranz et al., 2008).”
• The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. (2003, background): “Indeed, SNAIL induces EMT by repressing E-cadherin transcription (4, 5).”