Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain

By Jon-Kar Zubieta, Y. R. Smith, Joshua A. Bueller, Yanjun Xu, M. Kilbourn, D. Jewett, Charles R. Meyer, Robert A. Koeppe, C. Stohler. Science, 2001

841 citations recorded by the source corpus.

Subfields: Economics and Econometrics, Education

View Paper: https://www.semanticscholar.org/paper/088dbc10f2ea35df00bdf7835981989f19298444

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Citations in the corpus

• Activation of the opioidergic descending pain control system underlies placebo analgesia. (2009, methodology): “The basal ganglia (Bingel et al., 2002), the amygdala (Zubieta et al., 2005), the thalamus (Zubieta et al., 2001), and the pons (Petrovic et al., 2004) were corrected using spheres of 6 mm radius.”
• The neurobiology of itch (2006, background): “Should the hedonic experience be based on the release of endogenous opioids, as might be suggested from results in pain modulatio”
• Pain and the brain: Specificity and plasticity of the brain in clinical chronic pain (2010, neutral): “[111], who showed distinct brain activations corre-”
• Distraction modulates connectivity of the cingulo‐frontal cortex and the midbrain during pain—an fMRI analysis (2004, background): “Ligand-PET studies using the unselective opioid antagonist diprenorphine and the muselective opioid agonist carfentanil as tracers, were able to demonstrate a high opioid receptor density in the cingulofrontal region (Vogt, 1995; Willoch et al., 1999; Zubieta et al., 2001).”
• Neurobiological Mechanisms of the Placebo Effect (2005, background): “Under these conditions , activation of this neurotransmitter system is evidenced by reductions in the in vivo availability of synaptic ␮-opioid receptors to bind the radiolabeled tracer (Zubieta et al., 2001, 2002, 2003b; Bencherif et al., 2002).”
• A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation. (2005, background): “…of uORs is based on tactile (touch) elicitation of opiates as a means of reducing pain-induced emotional distress (Reisine & Pasternak 1996; Zubieta et al. 2001), and that this tactile–opiate relation was conserved throughout evolution to incorporate other opiate-induced functions by…”
• Human brain mechanisms of pain perception and regulation in health and disease (2005, background): “…Hypnotic suggestions for pain sensation S1 Pain-evoked activation modulated by suggestions for increased or decreased pain sensation Longe et al. (2001) fMRI Attention, distraction ACC, IC, Th Distracting vibratory stimulus reduced pain- evoked activity Ploghaus et al. (2001) fMRI Anxiety…”
• New Look at Social Support: A Theoretical Perspective on Thriving through Relationships (2014, background): “…the brain, which is associated with reduced amygdala activation (Inagaki & Eisenberger, 2012) and high densities of oxytocin and opioid receptors (Zubieta et al., 2001) that have implications for reduced sympathetic nervious system (SNS) and hypothalamic-pituitary-adrenal (HPA) responses…”
• Role of the Prefrontal Cortex in Pain Processing (2018, background): “Rheumatoid arthritis, trigeminal neuralgia, central post-stroke pain, and acute experimental pain all lead to decreased binding of opioid ligands in pain processing regions such as the ACC, PFC, parietal and temporal cortex, amygdala, thalamus, caudate, pons, and cerebellum during the painful period”
• A comprehensive review of the placebo effect: recent advances and current thought. (2008, background): “They also have found that these reductions are accompanied by increases in neural activity within brain areas known to be involved in emotional regulation (Fields 2004, Petrovic et al. 2005, Zubieta et al. 2001).”
• Brain mechanisms of pain affect and pain modulation. (2002, background): “by a reduction in pain [50] and may contribute to placebo”
• A common neurobiology for pain and pleasure (2008, background): “Both painful and pleasant events are associated with the release of endogenous μ-opioids in the brain and, importantly, in the NA”
• Traditional Chinese Acupuncture and Placebo (Sham) Acupuncture Are Differentiated by Their Effects on μ-Opioid Receptors (MORs) (2009, methodology): “…both short- and long-term effects of TA, areas showing increases in BP included a number of brain regions classically implicated in the regulation of pain and stress in humans (Zubieta et al., 2001, 2003b), such as the amygdala, the dorsal and perigenual anterior cingulate, and the insular cortex.”
• The brain opioid theory of social attachment: a review of the evidence (2011, background): “Zubieta et al. (2001) demonstrated that painful stimuli result in opioid ac tivation in the amygdala, thalamus, hypothalamus and nucleus accumbens) and deactivation in the dorsal anterior cingulate cortex (dACC), periaque ductal grey area (PAG) and Brodman areas 8 and 9 of the prefrontal cortex.”
• Towards a theory of chronic pain (2008, positive): “Such an approach has been used recently, for example, to differentiate brain activations in acute pain in relation to modulation with opiate analgesia using PET studies (Zubieta et al., 2001; Zubieta et al., 2002).”
• Synchrony as an Adaptive Mechanism for Large-Scale Human Social Bonding (2016, positive): “…(Loh et al.1976), and much evidence suggests that endorphins are central in the pain management system (Levine et al. 1979; Basbaum & Fields 1984; Janal et al. 1984; D’Amato & Pavone 1993; Benedetti 1996; Zubieta et al. 2001; Fields 2007; Bodnar 2008; Dishman & O’Connor 2009; Mueller et al. 2010).”