Human brain mechanisms of pain perception and regulation in health and disease

By Apkar Vania Apkarian, M. Bushnell, Rolf-Detlef Treede, Jon-Kar Zubieta. European Journal of Pain, 2005

3,072 citations recorded by the source corpus.

Subfields: Anesthesiology and Pain Medicine, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/9b9087bbe84889bca98f65c7c6dd1b92fb15d71b

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Citations in the corpus

Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain? (2007, methodology): “…that in fibromyalgia patients, gray matter loss occurred mainly in regions related to stress [parahippocampal gyrus (Herman et al., 2005)] and pain processing [cingulate, insular, and prefrontal cortices (Apkarian et al., 2005)], which might reflect their long-term experience of these symptoms.”
Persistent EEG overactivation in the cortical pain matrix of neurogenic pain patients (2006, methodology): “www.elsevier.com/locate/ynimg NeuroImage 31 (2006) 721 – 731 Persistent EEG overactivation in the cortical pain matrix of neurogenic pain patients Jair Stern,* Daniel Jeanmonod, and Johannes Sarnthein*”
Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits. (2013, background): “brain regions that encode back pain perception are regions that have been repeatedly observed to be activated for acute pain (Price, 2000; Apkarian et al., 2005), as identified by the metaanalytic map for the term pain.”
The influence of negative emotions on pain: Behavioral effects and neural mechanisms (2009, positive): “In the pain literature the ACC is one of the most consistently activated structures (Apkarian et al., 2005).”
Role of the Prefrontal Cortex in Pain Processing (2018, background): “Meta-analysis of studies employing experimental pain stimuli indicates the following brain areas to be positively associated with pain: primary and secondary somatosensory cortices, insular cortex, ACC, PFC, and thalamus [3].”
Two systems of resting state connectivity between the insula and cingulate cortex (2009, background): “The MCC includes regions involved in pain (Apkarian et al., 2005), and motor functions involved in response selection (aMCC) and skeletomotor body orientation (pMCC) (Vogt, 2005).”
Descending pain modulation and chronification of pain (2014, positive): “Numerous imaging studies have indicated that noxious stimuli activate several key brain regions, including cortical sites and limbic structures associated with emotional processing [20-22].”
Pain and the brain: Specificity and plasticity of the brain in clinical chronic pain (2010, background): “A large number of studies have demonstrated a network of brain areas consistently activated with acute thermal, mechanical, and chemical painful stimuli [4,15,100,101,112].”
The neural basis of empathy. (2012, background): “…prefrontal, primary and secondary somatosensory cortices (S1 and S2), dACC/aMCC, and insula, along with thalamic and brain stem regions such as the periaqueductal gray (PAG) (Apkarian et al. 2005, Bushnell et al. 1999, Derbyshire 2000, Peyron et al. 2000, Rainville 2002, Duerden & Albanese 2012).”
The effect of pain on cognitive function: a review of clinical and preclinical research. (2011, background): “Somatosensory cortical areas 1 and 2 (SI and SII), the insular cortex (IC), the thalamus, the prefrontal cortex (PFC) and the anterior cingulate cortex (ACC) have been identified as the six brain regions most commonly activated during pain processing (Apkarian et al., 2005).”
Psychological Considerations in the Assessment and Treatment of Pain in Neurorehabilitation and Psychological Factors Predictive of Therapeutic Response: Evidence and Recommendations from the Italian Consensus Conference on Pain in Neurorehabilitation (2016, background): “…these associations, c) factors linking pain and cognitive decline are still unclear, d) the direction of the cause-eﬀect relationship is still unclear (Apkarian et al., 2004, 2005, 2013; Berger et al., 2014), e) results can be partly explained by comorbidity with other disorders or the use of…”
Functional imaging studies of emotion regulation: A synthetic review and evolving model of the cognitive control of emotion (2012, neutral): “While responses to painful stimuli have a strong negatively-valenced affective component, this component may itself have a distinct neural signature due to its recruitment of dedicated pain-specific neural pathways 136, 137 .”
Chronic Pain and the Emotional Brain: Specific Brain Activity Associated with Spontaneous Fluctuations of Intensity of Chronic Back Pain (2006, methodology): “nonpainful touch (Price, 2000; Apkarian et al., 2005) in anticipation of pain (Ploghaus et al.”
Towards a theory of chronic pain (2008, positive): “…acute pain, stemming from anatomical findings that medial spinothalamic terminations project to prefrontal cortical targets, particularly the anterior cingulate (Apkarian et al., 2005), and also based on differential response properties of nociceptive neurons in the lateral versus medial thalamus.”
The placebo effect: From concepts to genes. (2015, positive): “…correlates of placebo and nocebo effects Pain processing has been associated with several brain regions including thalamus, primary and secondary somatosensory cortex (S1/S2), anterior cingulate cortex (ACC), and the insula (Peyron et al., 2000; Price and Barrell, 2000; Apkarian et al., 2005).”
An fMRI Study of Cytokine-Induced Depressed Mood and Social Pain: The Role of Sex Differences (2009, neutral): “(Apkarian et al., 2005; Aziz et al., 2000; Cechetto and Saper, 1987; Eisenberger et al., 2003).”