Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes.

By R. Hundal, K. Petersen, Adam Mayerson, P. Randhawa, Silvio E. Inzucchi, S. Shoelson, Gerald I. Shulman. Journal of Clinical Investigation, 2002

708 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0889cc0baca84335c6de858c464a8cbe69a4fdad

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Citations in the corpus

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB (2005, methodology): “We isolated IKK complexes from mouse liver lysates using anti-IKK-γ antibodies (PharMingen) coupled to protein A-Sepharose, and conducted in vitro kinase assays at 30 °C by adding [γ-32P]ATP and 2 μg of GST-IκBα (1-54)12.”
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. (2014, background): “Salicylate and salsalate Sodium salicylate and aspirin have demonstrated beneficial effects in the treatment of T2DM by improving glycaemic control through inhibition of NF-κB activity [72, 73].”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Moreover, inhibition of IKK in human diabetics by high-dose aspirin treatment also improves insulin signaling (Yin et al. 1998; Hundal et al. 2002).”
Inflammatory Mechanisms in the Regulation of Insulin Resistance (2008, background): “Whereas these effects might be mainly attributed to its effect on NF-κB inhibition (74), recent studies have also demonstrated that that high-dose aspirin (up to 7 g/day) improves glucose tolerance and triglyceride levels (120).”
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. (2012, positive): “Double-stranded RNA-dependent protein kinase (PKR) and I κ B kinase (IKK) are two stress-sensitive kinases that mediate serine phosphorylation of IRS-1 and are critical regulators of peripheral insulin resistance (36–39).”
The cellular and signaling networks linking the immune system and metabolism in disease (2012, background): “In humans, salicylate treatment enhanced insulin sensitivity in a small group of subjects with diabete”
Adipokines: the missing link between insulin resistance and obesity. (2008, background): “[112] Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, et al.”