An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.

By Theresa R. Bomfim, Letícia Forny‐Germano, Luciana B Sathler, Jordano Brito‐Moreira, J. Houzel, H. Decker, M. Silverman, H. Kazi, Helen M. Melo, P. McClean and 7 more. Journal of Clinical Investigation, 2012

813 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/158697cdd7dd559d541cb6fb357c21c8989fca89

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. John Q. Trojanowski
2. D. J. Drucker
3. Sérgio T. Ferreira
4. C. Zhong
5. F. D. De Felice
6. Zhichun Chen

In Pharmacology

1. Sérgio T. Ferreira
2. F. D. De Felice

In Physiology

1. Julie A. Schneider
2. David A. Bennett
3. R. Wilson
4. Zoe Arvanitakis
5. Bin Zhao
6. Zhou Liu
7. John Q. Trojanowski
8. Chunmei Jiang

Citations in the corpus

• Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “Actually, there is a huge body of evidence supports impaired insulin signaling to be the fundamental correlation between T2DM and AD (Bomfim et al., 2012; Zhao et al., 2008a,b).”
• Pharmacology, physiology, and mechanisms of incretin hormone action. (2013, background): “…3 weeks, intraperitoneal [i.p.]) prevented Ab-induced JNK activation and decreased serine phosphorylation in hippocampal neurons frommale amyloid precursor protein (APP)/PS1 transgenic mice, leading to improved brain insulin signaling, spatial memory, and memory retention (Bomfim et al., 2012).”
• Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. (2012, positive): “The increases in IRS-1 pS 312 , IRS-1 pS 616 , and IRS-1 pS 636/639 are probably caused by correlated increases in activated IRS-1 serine kinases (ERK2, IKK, JNK1/2, mTOR, and PKC ζ / λ ), potentially resulting from elevated oligo-meric A β .”
• Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease (2014, background): “In T2D, activation of the stress kinase c-Jun NH2terminal kinase (JNK) phosphorylates IRS-1 at serine residues (IRS-1pSer), blocking downstream insulin signaling and causing peripheral insulin resistance (28).”
• The Gut Microbiota and Alzheimer’s Disease (2017, positive): “Moreover, glucagon-like peptide 1 receptor agonists can protect the brain from defective insulin signaling and improve cognition in a transgenic AD mouse model [135].”
• Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies (2024, background): “331,341 Dysregulated neurotrophic signaling pathway Neurotrophic factors not only promote the survival, growth, and differentiation of neurons but are also crucial for maintaining synaptic plasticity and neuronal signaling functions.”