The SLC16 gene family—from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

By A. Halestrap, D. Meredith. Pflügers Archiv, 2004

1,081 citations recorded by the source corpus.

Subfields: Biochemistry, Clinical Biochemistry, Physiology

View Paper: https://www.semanticscholar.org/paper/0883960bd206ebd509aa17a98752aa22e311cdeb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. M. V. Vander Heiden
2. J. Pouysségur
3. A. Halestrap
4. G. Brent

In Clinical Biochemistry

1. M. V. Vander Heiden
2. A. Halestrap
3. Pierre J. Magistretti
4. Luc Pellerin

In Physiology

1. M. V. Vander Heiden
2. J. Pouysségur
3. M. Brahimi-Horn
4. J. Chiche
5. E. Canfora
6. Ellen E. Blaak
7. A. Halestrap
8. K. Verbeke

Citations in the corpus

• A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. (2004, background): “Finally, 14 monocarboxylate transporters (MCTs), also known as “family SLC16,” have been identified in humans, but little is known about their function (Halestrap and Meredith 2003).”
• The SLC3 and SLC7 families of amino acid transporters. (2013, background): “The monotopic ancillary protein CD147 is required for functional expression of MCT1 and MCT4 at the plasma membrane (Halestrap and Meredith, 2004).”
• The monocarboxylate transporter family—Structure and functional characterization (2012, background): “Considerable progress has been made in characterizing the properties of different members of the MCT family, and there is an increasing awareness that MCTs play critical metabolic roles in a wide range of normal and pathological conditions [see (2, 4, 8)].”
• Short chain fatty acids in human gut and metabolic health. (2020, positive): “The affinity of the basolateral SCFA/HCO 3 antiporter for butyrate is much lower compared to the apical transporter (Km = 17.5 vs 1.5 mM) suggesting that two different proteins are involved (Halestrap and Meredith, 2004; Harig et al. , 1996).”
• Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations (2009, background): “MCT9 is expressed in various tissues including the kidney [15].”
• The SLC16 gene family - structure, role and regulation in health and disease. (2013, background): “If pyruvate were lost this reaction could not occur and glycolysis would cease (Halestrap and Meredith, 2004; Halestrap and Wilson, 2012).”
• Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. (2008, methodology): “These activities are mediated by MCTs, among which MCT1–MCT4 are known to passively convey lactate across cell membranes (12, 13).”
• Supply and Demand in Cerebral Energy Metabolism: The Role of Nutrient Transporters (2007, background): “It is also expressed in chondrocytes, white blood cells, and in placenta, where it exports lactate from the fetal circulation (Halestrap and Meredith, 2004).”
• Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “Among the constitutively expressed plasma membrane-bound transporters and exchangers, the Na /H exchanger NHE-1 [16] and its isoforms [17], the vacuolar-type H -ATPase (V-ATPase) [18], the monocarboxylate transporters (MCTs) [19] and HCO3 transporters and exchangers (NBCs and AEs) [20, 21] cooperate”
• Targeting cancer metabolism: a therapeutic window opens (2011, background): “Additional potential side effects of inhibiting lactate transport include negative effects on other normal tissues — such as the liver, muscles and brain — that rely on lactate as a fuel in certain physiological situation”