MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.

By T. Callis, Kumar Pandya, H. Seok, Ruhang Tang, M. Tatsuguchi, Zhan-Peng Huang, Jian-Fu Chen, Zhongliang Deng, B. Gunn, Janelle A. Shumate and 3 more. Journal of Clinical Investigation, 2009

873 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/47508ebebf87a49a91fdeaf6771763d74b2cf802

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Citations in the corpus

A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. (2009, background): “In addition to the thyroid hormone receptor coregulator Thrap1, shown previously to be a target for repression by miR208a in the heart (van Rooij et al., 2007; Callis et al., 2009), we identified several transcriptional repressors among the predicted targets of the MyomiRs (Figure S4).”
Therapeutic Inhibition of miR-208a Improves Cardiac Function and Survival During Heart Failure (2011, positive): “12,13 Remarkably, both of these genes encode slow myosins and contain intronic miRNAs (miR-208b and miR-499, respectively).”
MicroRNAs in development and disease. (2011, background): “In contrast, myostatin, which is a negative regulator of hypertrophy (430), is a validated target of miR-208a that was suppressed in the transgenic heart and, thus, might explain the hypertrophic growth (69).”
Metazoan MicroRNAs (2018, background): “miR-208 (2) miR-208a Abnormal atrial cardiac conduction (Callis et al., 2009); reduced cardiac pathology in sponse to stress and in model of hypothyroidism (van Rooij et al.”
MicroRNAs in stress signaling and human disease (2012, background): “miR-208a is encoded by an intron of the a-MHC gene and is expressed specifically in the heart along with its host gene (Callis et al., 2009; van Rooij et al., 2007).”
Engineering Adolescence: Maturation of Human Pluripotent Stem Cell-derived Cardiomyocytes (2014, background): “Because of its involvement in thyroid hormone responsiveness and the myosin isoform switch, miR208 is a potential candidate that also may promote maturation.(103,104)”
Transcriptional Regulation and its Misregulation in Disease (2013, positive): “…types of cardiovascular disease, including arrhythmia, fibrosis, hypertrophy due to high pressure and misregulation of cardiac energy metabolism (Callis et al., 2009; Care et al., 2007; Grueter et al., 2012; Luo et al., 2008; Thum et al., 2008; van Rooij et al., 2007; van Rooij et al., 2008;…”
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis (2020, background): “miR-208a is encoded within the α-cardiac muscle myosin heavy chain genes, while miR-208b and miR-499 are encoded within introns of the β-cardiac muscle myosin heavy chain genes and are, therefore, regarded as heart-specific miRNAs [209], with all three of them belonging to the miR-208 family [210].”