The inflammasome: a danger sensing complex triggering innate immunity.
By Virginie Petrilli, Catherine Dostert, D. Muruve, J. Tschopp. Current Opinion in Immunology, 2007
739 citations recorded by the source corpus.
Subfields: Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/0841611e09972a97ca40b4dd94bc483ae341b9c9
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In Molecular Biology
- Shizuo Akira
- G. Núñez
- J. Tschopp
- T. Kanneganti
- O. Takeuchi
- L. Franchi
- F. Sutterwala
- Virginie Petrilli
In Surgery
Citations in the corpus
- Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “There is conclusive evidence now implicating NLR family members including NLRP1, NLRP3, and NLRP4 as critical factors in the activation of caspase-1 in response to proinflammatory stimuli (137, 138).”
- NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation (2010, background): “NOD2 is required for muramyldipeptide-mediated autophagy NOD2 is not the sole ligand for muramyldipeptide in monocyte-derived cells, as muramyldipeptide is also recognized by the NALP inflammasom”
- Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome (2008, background): “This complex is activated by multiple agonists including a bacterially derived muramyl dipeptide or endogenous ATP and uric acid, leading to the processing and release of IL-1 (10, 11).”
- TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future. (2014, background): “inflammation [297,298] now additionally implicated in the autoimmune inflammation of Crohn’s disease [299] and RA [292,296].”
- The Nalp3 inflammasome is essential for the development of silicosis (2008, background): “The mammalian NLR family is composed of over 20 members that contain a C-terminal leucine-rich repeat (LRR) domain, a central nucleotide-binding NACHT domain, and an N-terminal protein–protein-interaction domain composed of a CARD (caspase activation and recruitment domain) or pyrin domain (9, 10).”
- Inflammation and its role in age-related macular degeneration (2016, background): “Some attempts have been made to arrest the inflammasome signaling in the RPE, e.g. by blocking the priming phase with vinpocetine, a compound that inhibits the activity of NF-jB, or by preventing pro-caspase-1 processing by administering a virally transduced CARD domain of the adaptor protein ASC [9”
- Mechanisms of regulated unconventional protein secretion (2009, background): “In macrophages, caspase 1 has recently been shown to be activated by inflammasome”
- Innate Immunity to Virus Infection (2009, background): “Among these receptor types, TLRs and RLRs are important for the production of type I interferons (IFNs) and various cytokines, whereas NLRs are known to regulate interleukin-1b (IL-1b) maturation through activation of caspase-1 (4, 5).”