Cleavage of Arabidopsis PBS1 by a Bacterial Type III Effector

By F. Shao, C. Golstein, J. Ade, M. Stoutemyer, J. Dixon, Roger W. Innes. Science, 2003

597 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/08319da65c71ff4b9b3426f3ecf7446b504023b7

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In Plant Science

Citations in the corpus

Plant NBS-LRR proteins in pathogen sensing and host defense (2006, background): “AvrPphB is a cysteine protease and functions in the plant cell to cleave PBS1 at a specific sit”
A Novel Role for the TIR Domain in Association with Pathogen-Derived Elicitors (2007, background): “Additional support for the guard hypothesis comes from tomato Cf2 and the host protease Rcr3 [21], as well as from Arabidopsis RPS5 and PBS1 [22].”
Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. (2010, background): “syringae effector AvrPphB, a cysteine protease, triggers RPS5-specified disease resistance by proteolytically cleaving the cytoplasmic receptor-like kinase PBS1 (Ade et al., 2007; Shao et al., 2003).”
Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. (2005, background): “This idea is known as the guard model (24, 81), and it is the subject of intense investigation (7, 8, 74, 75, 78, 79, 101).”
Innate immunity in plants and animals: striking similarities and obvious differences (2004, background): “AvrPphB was found recently to proteolytically cleave PBS1, and this cleavage was required for RPS5-mediated resistance, indicating that AvrPphB is detected indirectly via its enzymatic activity (87).”
Type III secretion system effector proteins: double agents in bacterial disease and plant defense. (2004, background): “In the cases of AvrRpt2 and AvrPphB, their respective targets, RIN4 and PBS1, also are localized to the plasma membrane (15, 139).”
From Guard to Decoy: A New Model for Perception of Plant Pathogen Effectors (2008, background): “P. syringae AvrPphB, for example, cleaves the PBS1 kinase in the host Arabidopsis, resulting in recognition by the RPS5 R protein (Shao et al., 2003; Ade et al., 2007).”
Elicitors, effectors, and R genes: the new paradigm and a lifetime supply of questions. (2007, background): “syringae Avr gene, avrPphB, encodes a protease that is delivered into host cells via type III secretion, and AvrPphB specifically cleaves PBS1 (154).”
Host-microbe interactions: shaping the evolution of the plant immune response. (2006, unknown): “Molecular evidence for indirect pathogen recognition has come from work studying resistance responses in Arabidopsis plants following infection with P. syringae expressing the effector AvrPphB, a cysteine protease (Figure 3A) (Shao et al., 2003).”
A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. (2007, background): “Several plant proteins are known to interact with P. syringae effectors (Mackey et al., 2002; Axtell and Staskawicz, 2003; Mackey et al., 2003; Shao et al., 2003; Nomura et al., 2006).”
Signaling in Plant-Microbe Interactions (2013, background): “complex leads to RPS5 conformational changes, which trigger resistance (Shao et al. 2003).”
Intracellular innate immune surveillance devices in plants and animals (2016, background): “Similarly, RPS5 monitors the state of protein kinase PBS1, also at the plasmamembrane (67, 68).”
Plant NBS-LRR proteins: adaptable guards (2006, background): “There is increasing evidence from several systems that other R proteins similarly act as guards of host targets rather than direct receptors, at least for bacterial effectors [56-58].”