Mucin dynamics and enteric pathogens

By M. McGuckin, S. Lindén, P. Sutton, T. Florin. Nature Reviews Microbiology, 2011

1,392 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Surgery

View Paper: https://www.semanticscholar.org/paper/07f658ff430d2aaf5d934dd72045572842766886

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nutrition and Dietetics

1. G. Núñez
2. M. Esteban
3. Curtis Huttenhower
4. R. Cone
5. Herbert Tilg

In Surgery

1. G. Núñez
2. M. Esteban
3. Mark Atkinson
4. Curtis Huttenhower
5. S. Bischoff
6. Y. Belkaid
7. Herbert Tilg
8. T. Hand

Citations in the corpus

• Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation. (2017, background): “Together these observations suggest an increased availability of smaller mucin oligosaccharides (Larsson et al., 2011) and increased de-polymerization of MUC2 through the action of serine peptidases in this cohort of IBD patients (Abreu et al., 2016; McGuckin et al., 2011).”
• Oral Drug Delivery with Polymeric Nanoparticles: The Gastrointestinal Mucus Barriers (2011, background): “Pathogens and toxins that manage to bypass these protective mechanisms and breach the mucus barrier will induce more rapid mucus secretion, which serves to remove offending material [13, 35].”
• New developments in goblet cell mucus secretion and function (2015, neutral): “This penetrability of the small intestinal mucus may be the reason why pathogenic bacteria mostly infect this region of the gut using different mechanisms as discussed elsewhere.(16) The small intestinal mucus is normally easily aspirated and nonattached.”
• Homeostatic immunity and the microbiota (2017, neutral): “Intestinal mucus production provides a primary shield, by limiting contact between the microbiota and host tissue and preventing microbial translocation (McGuckin et al., 2011).”
• A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility (2016, positive): “Moreover, the mucus barrier—a reservoir of antimicrobial peptides and immunoglobulins—is the first structure that a mucosal pathogen must overcome to establish an infection (McGuckin et al., 2011).”
• Mucin glycan foraging in the human gut microbiome (2015, background): “…6 | Article 81 Edited by: Ines Thiele, University of Luxembourg, Luxembourg Reviewed by: Joel B. Mason, Tufts University, USA Xu Lin, Chinese Academy of Sciences, China *Correspondence: Nathalie Juge, The Gut Health and Food Safety Institute Strategic Programme, Institute of Food Research, Norwich”
• Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes (2011, background): “Mucin is well known as a glycoprotein produced by the host that contributes to gut integrity [42].”
• Intestinal permeability – a new target for disease prevention and therapy (2014, background): “These are also glycosylated and are released upon binding by microorganisms as a defense mechanism to prevent colonization [29,30].”
• An Overview of the Immunological Defenses in Fish Skin (2012, background): “Mucins are strongly adhesive, play a major role in the defence of the mucosae [112, 113], form a matrix in which a diverse range of antimicrobial molecules can be found [114], and impart viscoelastic and rheological properties to mucosal layers [115].”
• How bacterial pathogens colonize their hosts and invade deeper tissues. (2015, background): “[7] McGuckin MA, Linden SK, Sutton P, Florin TH.”
• Role of the Microbiota in Immunity and inflammation (2014, background): “The mucus represents the primary shield limiting contact between the microbiota and host tissue and preventing microbial translocation (McGuckin et al., 2011).”