Oral Drug Delivery with Polymeric Nanoparticles: The Gastrointestinal Mucus Barriers

By L. Ensign, R. Cone, J. Hanes. Advanced Drug Delivery Reviews, 2011

1,487 citations recorded by the source corpus.

Oral delivery is the most common method for drug administration. However, poor solubility, stability, and bioavailability of many drugs make achieving therapeutic levels via the gastrointestinal (GI) tract challenging. Drug delivery must overcome numerous hurdles, including the acidic gastric environment and the continuous secretion of mucus that protects the GI tract. Nanoparticle drug carriers that can shield drugs from degradation and deliver them to intended sites within the GI tract may enable more efficient and sustained drug delivery. However, the rapid secretion and shedding of GI tract mucus can significantly limit the effectiveness of nanoparticle drug delivery systems. Many types of nanoparticles are efficiently trapped in and rapidly removed by mucus, making controlled release in the GI tract difficult. This review addresses the protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier.

Subfields: Organic Chemistry, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/bc80b60d673665fe79dff26e9459a05bfe6d5b3f

How researchers see this paper

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In Organic Chemistry

1. K. El-Say
2. Hossam S. El-Sawy

In Pharmaceutical Science

1. K. El-Say
2. Hossam S. El-Sawy
3. Xueting Lin
4. B. Homayun
5. Hyo-Jick Choi

Citations in the corpus

• Nanoemulsion: Concepts, development and applications in drug delivery (2017, background): “factors like capability to undergo direct paracellular/transcellular transport[26, 27], prolonged gastric retention due to mucosal entanglement[28], also contribute in nanoemulsion mediated bioavailability enhancement.”
• Polymeric nanoparticles: Promising platform for drug delivery. (2017, background): “Besides, nanoparticle drug carriers that can shield drugs from degradation and deliver them to intended sites within the GIT may enable more efficient and sustained drug delivery (Ensign et al., 2012).”
• Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals (2019, background): “There is an eq ilibrium betwee mucin secretion, degradation nd learance in each segment of the GI tract to protec the epithelium and control he nutrition absorption rate, which in turn defi es e fi al thickness of the regi n mucosal layer (Table 1) [38,90].”
• PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, neutral): “In addition to the harsh GI environment, NPs administered to the GI tract encounter rapidly cleared layers of viscoelastic and adhesive mucus [162].”