Identification of cells initiating human melanomas

By T. Schatton, G. Murphy, N. Frank, K. Yamaura, A. Waaga-Gasser, M. Gasser, Q. Zhan, Stefan Jordan, L. Duncan, C. Weishaupt and 4 more. Nature, 2008

1,375 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/07abddde44726dc05ca2d94e0563ad9c5a0d2634

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

In Oncology

Citations in the corpus

Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, methodology): “Based on previous published reports regarding CSCs in solid tumors [7–21], the following markers were studied: CD24, CD44, CD133, and CD166.”
Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, background): “When human melanomas were first transplanted into NOD/ SCID mice, it was estimated that only one in a million melanoma cells were capable of forming tumors, and melanoma was proposed to follow a cancer stem cell model (Schatton et al., 2008).”
Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “…initiation potential. et al., 1994), breast (Al-Hajj et al., 2003), brain (Galli et al., 2004; Lee et al., 2006; Singh et al., 2004), melanoma (Schatton et al., 2008), colon (O’Brien et al., 2007), and pancreatic cancer (Hermann et al., 2007), and the presence of these tumor subsets correlate…”
ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. (2009, background): “This gives data on the frequency of repopulating mammary cells from a tumorigenic mouse model (Vaillant et al., 2008).”
Cancer Stem Cells (2007, background): “To identify cancer stem cells (CSCs), several steps of experiments are required (1) cancer masses derived from patients should be dissociated into single cells mechanically and chemically; (2) dissociated cells are classified into several groups according to expressional status of one or several sur”
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment (2009, background): “ABCB5 was found to be expressed on a distinct subset of chemoresistant CD133 melanoma cells (32), and its selective targeting caused tumor growth inhibition in xenograft models (11).”
LOSS OF 5-HYDROXYMETHYLCYTOSINE IS AN EPIGENETIC HALLMARK OF MELANOMA (2012, methodology): “…Surgery and Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, New York, NY 10065, USA 13These authors contributed equally to this work *Correspondence: gmurphy@rics.bwh.harvard.edu (G.F.M.), yujiang_shi@hms.harvard.edu (Y.G.S.) http://dx.doi.org/10.1016/j.cell.2012.07.033”
Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy (2008, background): “In analogy to hematopoietic stem cells, solid tumor CSC have been proposed to exhibit high level expression of multidrug transporter family genes, such as ABCG2 and ABCB5, likely resulting in more efficient efflux of chemotherapeutic drugs [13– 15].”
Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized (2010, methodology): “However, the xenotransplantation experiments that were the basis for these conclusions were carried out with assays in which an average of only 1 in 50,000 (see Table S3 in Boiko et al., [2010]) to 1 in 1,090,000 (Schatton et al., 2008) unfractionated melanoma cells formed tumors.”
Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “The first conclusive evidence for CSCs was published in 1997 [286], and to date CSCs have been isolated from both leukemias and a variety of solid tumors, including breast, brain, pancreatic, prostrate, ovary, and colon cancers [287-293].”
Transient Low Doses of DNA Demethylating Agents Exert Durable Anti-tumor Effects on Hematological and Epithelial Tumor Cells (2012, background): “…for leukemia and solid tumor cells (Lapidot et al., 1994; Al-Hajj et al., 2003; Li et al., 2007; O’Brien et al., 2007; Ricci-Vitiani et al., 2007; Schatton et al., 2008; Singh et al., 2004) is engraftment capability and tumor growth of the most tumorigenic or more ‘‘stem-like’’ cells in mice…”