ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays.

By Yifang Hu, Gordon K. Smyth. JIM - Journal of Immunological Methods, 2009

2,040 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/26781e93892cbcb0faf45bd86f4a13487da9cf5e

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In Molecular Biology

1. R. Weinberg
2. Chuan He
3. Hans Clevers
4. Hailing Shi
5. J. Dick
6. E. Batlle
7. Jianjun Chen
8. Huilin Huang

Citations in the corpus

• The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. (2011, methodology): “Frequency of tumor-initiating cells was estimated according to published methods (Hu and Smyth, 2009).”
• Stem cell gene expression programs influence clinical outcome in human leukemia (2011, methodology): “The lower estimate of frequency in cases without negative results was estimated using ELDA (WEHI, Bioinformatics Division”
• Targeting FTO suppresses cancer stem cell maintenance and immune evasion (2020, positive): “ELDA software (Hu and Smyth, 2009) was utilized to evaluate the frequency of LSC/LICs.”
• Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State (2012, methodology): “For limiting dilution analyses, the frequency of MaSCs in the cell population being transplanted was calculated using the Extreme Limiting Dilution Analysis Program (http://bioinf.wehi.edu.au/ software/elda/index.html) (Hu and Smyth, 2009).”
• Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized (2010, methodology): “yses were carried out using ELDA: Extreme Limiting Dilution Analysis (Hu and Smyth, 2009).”
• Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. (2012, positive): “Lung TIC frequencies were estimated using ELDA software (Hu and Smyth, 2009).”
• METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification (2017, methodology): “ELDA software (Hu and Smyth, 2009) was used to estimate the frequency of leukemia stem/initiating cells (LSCs/LICs).”