Cancer Stem Cells

By J. McNamara. Methods in Molecular Biology, 2007

1,678 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/793479da553db1dee83b1056bacf2553348f420f

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Citations in the corpus

Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer (2009, background): “The existence of lung CSCs could explain why current treatments for lung cancer cannot consistently eradicate tumor cells and ‘‘have reached a therapeutic plateau,’’ because these therapies target the bulk of cancer and are unlikely to eliminate CSCs (3, 4).”
CD44 is of Functional Importance for Colorectal Cancer Stem Cells (2008, background): “It is believed that CSC has the characteristics of normal adult stem cells including the selfrenewal property and multipotency for differentiation into distinct types of cells (4, 5).”
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity (2008, background): “Whether such a CSC niche really exists and which cells constitute this niche in vivo remains to be established (23), but proving its existence or identification of the signals that regulate CSC proliferation and differentiation could be of vital importance for therapeutic strategies to prevent tumor”
Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients (2008, background): “org Clin Cancer Res 2008;14(1) January1, 2008 125”
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. (2007, background): “More recently, however, increasing evidence suggests that stem cells may play a decisive role not only in the generation of complex multicellular organisms but also in the development and progression of tumors (Clarke et al., 2006; Jordan et al., 2006).”
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells (2009, background): “According to the cancer stem cell model, tumors are organized as a cellular hierarchy maintained by a small pool of self-renewing cancer stem cells that must be eliminated in order to eradicate the tumor (Jordan et al., 2006; Reya et al., 2001).”
Cancer epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance (2014, background): “From a histologic and cell population standpoint phenotypic heterogeneity in tumor tissues has long been observed (Beck and Blanpain, 2013; Nguyen et al., 2012; Wang and Dick, 2008).”
SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma (2009, background): “The cancer stem cell hypothesis posits that tumorigenic potential is largely restricted to a subset of self-renewing tumor cells with stem cell-like properties designated as tumor stem cells (TSCs) or tumor-initiating cells (TICs) (Clarke et al., 2006; Jordan et al., 2006; Reya et al., 2001).”
Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. (2010, background): “cancer-initiating cells, which exhibit a self-renewal capacity and are responsible for tumor maintenance and metastasis (26).”
Transient Low Doses of DNA Demethylating Agents Exert Durable Anti-tumor Effects on Hematological and Epithelial Tumor Cells (2012, background): “, 2004) is engraftment capability and tumor growth of the most tumorigenic or more ‘‘stem-like’’ cells in mice (Jordan et al., 2006).”
Single-cell dissection of transcriptional heterogeneity in human colon tumors (2011, background): “For example, although it has been postulated that multilineage differentiation can contribute to tumor heterogeneit”