History of Discovery: The LDL Receptor

By J. Goldstein, Michael S. Brown. Arteriosclerosis, Thrombosis and Vascular Biology, 2009

1,213 citations recorded by the source corpus.

Summary In this article, the history of the LDL receptor is recounted by its co-discoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.

Subfields: Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/07454448ce880a85d8d07ff99afe274c1b5fc1ac

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Peter Libby
2. P. Ridker
3. G. Hansson
4. Michael S. Brown
5. J. Goldstein
6. K. Thompson
7. Vikas Kumar
8. N. Romano

In Surgery

1. Peter Libby
2. G. Hansson
3. J. Goldstein
4. Michael S. Brown
5. P. Ridker
6. I. Tabas
7. K. Bornfeldt
8. L. Melvin

Citations in the corpus

• A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins (2015, positive): “Schoenheimer’s discovery also laid the groundwork for the discovery of the LDL receptor in the 1970s (Goldstein and Brown, 2009) and the Scap/SREBP pathway in the 1990s (Brown and Goldstein, 2009).”
• INCREASED HEPATIC SYNTHESIS AND DYSREGULATION OF CHOLESTEROL METABOLISM IS ASSOCIATED WITH THE SEVERITY OF NONALCOHOLIC FATTY LIVER DISEASE (2012, background): “It is well known that uptake of LDL-C via LDLR provides feedback inhibition of HMGCR by inhibition SREBP-2 activation (Goldstein and Brown, 2009).”
• LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus (2013, background): “, by pretreatment with statins (53)] might increase the efficacy of such vectors.”
• Pathophysiology of Atherosclerosis (2022, background): “On the other hand, when LDLs are extensively modified, they become unrecognizable by the LDLR, while allowing recognition by a range of scavenger receptors [105–108].”
• Metabolism and Nutritive Role of Cholesterol in the Growth, Gonadal Development, and Reproduction of Crustaceans (2018, background): “Second, similar to LDL transport in mammalian cells, LP can be endocytosed by the cells of the fat body (Goldstein and Brown, 2009).”
• Dyslipidemia in Obesity: Mechanisms and Potential Targets (2013, background): “In contrast, LDL is primarily taken up by the liver via the LDL receptor [31,32].”
• Progress and challenges in translating the biology of atherosclerosis (2011, background): “In particular, LDL levels satisfy modified Koch's postulates — criteria for judging whether a specific microbe is the cause of a disease — for causality of atherosclerosi”