Intestinal epithelial cells secrete exosome-like vesicles.

By Guillaume van Niel, G. Raposo, C. Candalh, Muriel Boussac, R. Hershberg, N. Cerf‐Bensussan, M. Heyman. Gastroenterology, 2001

711 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/071478619b59a2532850ce1317c0d36c30441b8e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. G. Raposo
2. C. Théry
3. Marina Colombo
4. W. Stoorvogel
5. Guillaume van Niel
6. N. Manel

In Molecular Biology

1. G. Raposo
2. C. Théry
3. Marina Colombo
4. A. Llorente
5. J. Kowal
6. M. Tkach
7. W. Stoorvogel
8. María Yáñez-Mó

Citations in the corpus

• Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “EVs released apically or basolaterally by intestinal epithelial cells appear to be involved in antigen presentation at inflammatory conditions, and these EVs may confer the ability of static epithelial cells to act at a distance (van Niel et al., 2001).”
• Biogenesis and secretion of exosomes. (2014, positive): “The existence of this unusual EV secretion pathway was confirmed afterwards in, among others, antigen-presenting cells [8,9], epithelial cells [10] and tumour cells [11].”
• The Biogenesis and Functions of Exosomes (2002, background): “Exosomes can indeed have tolerizing functions, as emphasized by the recent finding that intestinal epithelial cells, in inflammatory conditions, secrete MHC class II-carrying exosomes into the blood (22,23).”
• Exosomes: a common pathway for a specialized function. (2006, methodology): “Epithelial cell– derived exosomes, through their ability to be secreted apically and basolaterally, may be used for elimination of unwanted molecules in the lumen and for the transfer of luminal antigenic information towards the mucosal immune tissue (10).”
• Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “…to secrete exosomes in vitro, based on the presence of MVBs and the enrichment of MVB components in the secreted vesicles, including epithelial cells (Van Niel et al. 2001), neurons (Fauré et al. 2006), Schwann cells (Fevrier et al. 2004), and tumor cells (Wolfers et al. 2001), among others.”
• Biological properties of extracellular vesicles and their physiological functions (2015, background): “In polarized cells, EVs derived from the apical and basal membrane differed in their content (554).”