Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.

By Shunyou Wang, Jing Gao, Q. Lei, N. Rozengurt, C. Pritchard, J. Jiao, G. Thomas, Gang Li, P. Roy-burman, P. Nelson and 2 more. Cancer Cell, 2003

1,112 citations recorded by the source corpus.

Subfields: Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/0604bee2a966dd6d4c53a38bb3dd8f56951aa643

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In Molecular Biology

In Pulmonary and Respiratory Medicine

J. Engelman

Citations in the corpus

Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size (2005, background): “Tissuespecific activation of this pathway, either by the overexpression of active PI3K or Akt or by a deletion of PTEN, results in an increase in the sizes of several organs, including the heart (19, 48, 64–66), the endocrine pancreas (70), the brain (2, 30, 37), lymphoid tissue (27), the prostate (”
Tenets of PTEN tumor suppression. (2008, background): “Various mouse models in which Pten is deleted also demonstrate the crucial role of PTEN as a tumor suppressor in multiple tumor types (Di Cristofano et al., 1998; Podsypanina et al., 1999; Suzuki et al., 1998; Trotman et al., 2003; Wang et al., 2003).”
Molecular genetics of prostate cancer: new prospects for old challenges. (2010, methodology): “Trotman et al. 2003; Wang et al. 2003 Selected models represent the range of phenotypes, transforming events, and allelic alterations that are available for studying prostate cancer in GEM mice. of chemopreventive agents.”
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. (2007, neutral): “…and conditional Pten mutant mice, which develop carcinomas of the skin, prostate, colon, breast, and endometrium, as well as thymic lymphomas , among other cancers (Di Cristofano et al., 1998; Li et al., 2002; Podsypanina et al., 1999; Suzuki et al., 2001; Wang et al., 2003; You et al., 2002).”
Genetics and biology of prostate cancer (2018, result): “Indeed, combined inhibition of PI3K/AKT and AR signaling can provoke robust regressions in Pten-deficient GEMMs and human PDX models (Carver et al. 2011; Mulholland et al. 2011).”
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism (2006, background): “Tissue-specific homozygous deletion of PTEN in the prostate epithelium leads to aggressive prostate carcinom”
Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures (2010, methodology): “(B) Increasing overlap of castration signature with PTEN-knockout-driven prostate cancer over time (minimum HP 10 (27)) (22,27).”