Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size
By R. Easton, Han Cho, K. Roovers, D. Shineman, M. Mizrahi, M. Forman, V. Lee, M. Szabolcs, R. de Jong, T. Oltersdorf and 3 more. Molecular and Cellular Biology, 2005
520 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/f3645b329eddc307e9018ed8654fd98123b526fa
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In Cellular and Molecular Neuroscience
In Molecular Biology
- David M. Sabatini
- T. Franke
- C. Thoreen
- D. Guertin
- D. Iliopoulos
- Jason Moffat
- M. Laplante
- R. A. Saxton
Citations in the corpus
- Akt1 controls macrophage response to LPS by regulating microRNAs (2009, background): “In mammals, the Akt family consists of three isoforms, Akt1 (PKBa), Akt2 (PKBb), and Akt3 (PKBg), which are functionally distinct despite their sequence similarities (Cho et al., 2001; Easton et al., 2005; Mao et al., 2007; Maroulakou et al., 2007; Yang et al., 2005).”
- PI3K/Akt: getting it right matters (2008, background): “…placental hypotrophy, accompanied by retardation of growth and reduction of body weight (Chen et al., 2001; Cho et al., 2001b); Akt2( / ) mice become hyperinsulemic and hyperglycemic (Cho et al., 2001a); and Akt3( / ) mice exhibit reduced brain sizes (Easton et al., 2005; Tschopp et al., 2005).”
- Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. (2006, background): “Three Akt/PKB genes with redundant functions exist in mammals (Akt1/PKBa, Akt2/ PKBb, and Akt3/PKBg), and genetic disruption of any one Akt/PKB gene results in viable animals (Chen et al., 2001; Cho et al., 2001; Easton et al., 2005; Garofalo et al., 2003).”