Liquid-liquid phase separation in biology.

By Anthony A. Hyman, C. Weber, Frank Jülicher. Annual Review of Cell and Developmental Biology, 2014

2,750 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f5504f3b109b22b2351100c07453a9f234c8ee56

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Citations in the corpus

Compositional Control of Phase-Separated Cellular Bodies (2016, neutral): “These and other behaviors suggest that cellular bodies are condensed phases that form through liquid-liquid phase separation of the nucleo- or cytoplasm (Hyman et al., 2014).”
Residue-by-residue view of in vitro FUS granules that bind the C-terminal domain of RNA polymerase II (2015, neutral): “The phenomenon of liquid-liquid phase separation has garnered much attention due to recent observations of liquid-like behavior of several cellular punctate and droplet structures including ribonucleoprotein granules and the nucleolus (Hyman et al., 2014).”
Alternative RNA Conformations: Companion or Combatant (2022, background): “The liquid–liquid phase separation is an important phenomenon, whereby specific RNAs, proteins and other molecules are organized into separate granules [65,66].”
Tau protein liquid–liquid phase separation can initiate tau aggregation (2018, positive): “Cells use LLPS to reversibly assemble membrane-less organelles such as stress granules, p-granules, or nucleoli (reviewed in Mitrea et al , 2016; Hyman et al , 2014).”
Protein Phase Separation: A New Phase in Cell Biology (2018, background): “These questions are starting to be answered, and recent advances in inter-disciplinary approaches have fueled the emergence of insights into their organization, molecular properties and regulation [2-4].”
Phase separation in biology; functional organization of a higher order (2016, background): “This concept is supported by a growing body of evidence identifying proteins, sometimes co-mixed with nucleic acids, that phase separate in vitro into dense liquid-like [46–49] or hydrogel [50, 51] structures (reviewed in [52]).”
Random-phase-approximation theory for sequence-dependent, biologically functional liquid-liquid phase separation of intrinsically disordered proteins (2016, methodology): “The recent discovery of biologically functional IDPs as individual molecules and also collectively via phase-separation has sparked a renewed interest in polymer solution theories [27,33,89,90].”
Stress-triggered phase separation is an adaptive, evolutionarily tuned response (2017, background): “Groundbreaking work has focused on phase separation as a mechanism to compartmentalize an otherwise-well-mixed milieu (Feric et al., 2016; Hyman et al., 2014; Li et al., 2012; Su et al., 2016).”