Liquid phase condensation in cell physiology and disease

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A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins (2018, neutral): “These membraneless compartments have been termed biomolecular condensates, because their material properties resemble those of liquids, gels, or solids (Banani et al., 2017; Shin and Brangwynne, 2017).”
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization (2022, background): “This adds to the growing appreciation that intrinsic disorder, which is much more prevalent in eukaryotic than in prokaryotic proteomes ( 84 , 85 ), plays a key role in the functional sub-compartmentalization of the eukaryotic nucleo-and cytoplasm in the context of biomolecular condensation ( 86 ).”
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis (2019, background): “Shodai et al., 2013 208–265 ThT, TEM, CD, SAXS Truncated RRM2 domain forms ThT-negative fibrillar aggregates.”
Transcription factors activate genes through the phase separation capacity of their activation domains (2018, background): “These dynamic interactions are also typical of the IDRIDR interactions that facilitate formation of phase-separated biomolecular condensates (Alberti, 2017; Banani et al., 2017; Hyman et al., 2014; Shin and Brangwynne, 2017; Wheeler and Hyman, 2018).”