Molecular machines governing exocytosis of synaptic vesicles
By R. Jahn, D. Fasshauer. Nature, 2012
953 citations recorded by the source corpus.
Calcium-dependent exocytosis of synaptic vesicles mediates the release of neurotransmitters. Important proteins in this process have been identified such as the SNAREs, synaptotagmins, complexins, Munc18 and Munc13. Structural and functional studies have yielded a wealth of information about the physiological role of these proteins. However, it has been surprisingly difficult to arrive at a unified picture of the molecular sequence of events from vesicle docking to calcium-triggered membrane fusion. Using mainly a biochemical and biophysical perspective, we briefly survey the molecular mechanisms in an attempt to functionally integrate the key proteins into the emerging picture of the neuronal fusion machine.
Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/81f94a2c9cac527411bb4d864a209dab232081cf
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In Cell Biology
In Cellular and Molecular Neuroscience
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Citations in the corpus
- Spontaneous network activity and synaptic development (2013, neutral): “As neurons begin to form synapses with each other, transmitters are increasingly released by vesicle fusion at specialized presynaptic active zones (Jahn and Fasshauer 2012).”
- Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Some of the mature granules under the membrane will dock to the PM, but these predocked vesicles still have to undergo “priming” to become the “readily releasable pool” that is first fused upon stimulation (312, 715, 1191).”
- Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle (2013, background): “Representative traces are shown on the left and summary graphs on the right.”