Regulation of MAP kinase signaling modules by scaffold proteins in mammals.

By D. Morrison, R. Davis. Annual Review of Cell and Developmental Biology, 2003

843 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/0546e01bbbbb4bb8bbe5fe02fe429402dde249bb

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In Molecular Biology

1. R. Roskoski
2. R. Seger
3. Walter Kolch
4. J. Avruch
5. J. Kyriakis
6. A. Nebreda
7. Yoav D. Shaul
8. E. K. Kim

In Oncology

1. R. Roskoski
2. J. Avruch
3. J. Kyriakis
4. R. Seger
5. A. Nebreda
6. E. Wagner
7. C. Weston
8. M. McKay

Citations in the corpus

• The JNK signal transduction pathway. (2007, background): “The mechanism that mediates the effects of JIP1 on JNK activation has not yet been fully established.”
• Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, background): “The regulation of Ras by receptor tyrosine kinases, and the consequent recruitment by Ras of the Raf family of MAP3Ks have been extensively reviewed (23, 192, 201, 203).”
• MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA (2006, neutral): “Jnk-interacting protein (JIP) scaffolding proteins interact with individual kinases in the cascade to allow effective activation of Jn”
• Receptor for RACK1 Mediates Activation of JNK by Protein Kinase C (2005, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript arrestin, and JSAP1 (Morrison and Davis, 2003) as well as by the protein phosphatase MKP5 (Theodosiou et al., 1999).”
• The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions (2006, background): “One of the best-studied scaffolds of the ERK cascade is the kinase suppressor of Ras (KSR (Morrison 2001)), which is constitutively associated with MEK1/2, 14-3-3 proteins, C-TAK1 and IMP and is localized primarily in the cytosol (Matheny et al. 2004; Morrison and Davis 2003).”
• ERK/MAPK signalling pathway and tumorigenesis (2020, background): “These regulatory factors affect bispecific phosphatases (7‐10), scaffold proteins (11-14), signal duration and intensity (15), and the dynamic subcellular localization of cascade components (16,17).”
• Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “β-Arrestin 2 acts as a scaffold protein for both the ERK and JNK signaling pathway [5,6] (Fig.”
• Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases (2007, background): “…internalization of cell surface receptors, the association of MAPK signalling components with scaffold proteins, and the balance between kinase activation and negative regulatory controls such as protein phosphatases (Volmat and Pouyssegur, 2001; Morrison and Davis, 2003; Murphy and Blenis, 2006).”
• MAP kinase signalling pathways in cancer (2007, background): “These complexes include scaffolds such as KSR (Therrien et al., 1996) and SUR-8/SHOC-2 (Li et al., 2000) which modulate the activation of Raf by Ras.”