If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells.

By I. Roninson, E. Broude, B. Chang. Drug resistance updates, 2001

765 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/04f9f655431d5a9df121cedae8a4776dec4f484c

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Citations in the corpus

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. (2002, background): “BM-induced tissue polarity is necessary for apoptosis resistance regardless of growth status Cytotoxic drugs induce apoptosis in target cells based upon their capacity to promote cell-cycle arrest (Roninson et al., 2001; Hurley, 2002).”
Pathways of apoptotic and non-apoptotic death in tumour cells (2004, background): “Importantly, the fraction of tumour cells that undergo non-apoptotic death increases if apoptosis is inhibited in response to anticancer agents or radiatio”
Mitotic catastrophe: a mechanism for avoiding genomic instability (2011, background): “In this case, cell death can occur quickly, within hours after mitotic exit, or in a delayed fashion, as exemplified by the 'delayed radio-induced cell death' that can occur years after radiotherapy in human tissue”
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011, methodology): “employ the term ‘mitotic catastrophe’ for cell death occurring in mitosis.(106,107) More frequently, mitotic catastrophe refers to cases of cell death that are triggered by aberrant mitosis and”
Cell death by mitotic catastrophe: a molecular definition (2004, background): “…microtubule-hyperpolymerizing agents (taxanes, elutherobins, epothilones, laulimalide, sarcodictyins, docodermolide) and by microtubule-depolymerizing agents (such as the Vinca alkaloids, cryptophyscins, halichondrins, estramustine and colchicine) as well as by DNA damage (Roninson et al., 2001).”
Radiation-induced cell death mechanisms (2010, background): “Aberrant mitosis produce an atypical chromosome segregation and cell division and leads to the formation of giant cells with aberrant nuclear morphology [71, 72, 74], multiple nuclei [72, 75], and/or several micronuclei [ 68 ] (Fig. 3). Two important mechanisms for the induction of the mitotic catas”
The role of p53 in determining sensitivity to radiotherapy (2003, background): “Mitotic catastrophe is a significant cause of cell death in different tumour cell lines after treatment with DNA-damaging agents, including I”