Genetic variegation of clonal architecture and propagating cells in leukaemia

By K. Anderson, C. Lutz, F. V. Delft, C. Bateman, Yanping Guo, S. Colman, H. Kempski, A. Moorman, I. Titley, J. Swansbury and 3 more. Nature, 2011

857 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/03df827fa18121b20e363a22b5a28cfac2dc5492

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Citations in the corpus

SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution (2014, background): “The emerging picture from these studies, across a diversity of solid [6,8,9,11,13,16] and hematological [4,5,7,10,12,14,15,17,22] disorders, is that tumors are both spatially [9,13,16] and temporally [4–17] heterogeneous and are frequently comprised of a single founding clone and several subclones.”
Cancer stem cells: an evolving concept (2012, background): “These include the remarkable finding that even rare mutations can be independently recurren”
The Life History of 21 Breast Cancers (2012, methodology): “…at different times (Ding et al., 2012; Shah et al., 2009), from different sites (Campbell et al., 2010; Ding et al., 2010; Yachida et al., 2010), at hypermutable genomic loci (Campbell et al., 2008), or through single-cell isolation (Anderson et al., 2011; Navin et al., 2011; Notta et al., 2011).”
Cancer heterogeneity: implications for targeted therapeutics (2013, background): “There is now compelling evidence to support a branched evolutionary pattern of tumour growth across many haematological (Anderson et al, 2011) and solid tumours (Shah et al, 2009; Campbell et al, 2010; Yachida et al, 2010; Gerlinger et al, 2012; Wu et al, 2012).”
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma (2014, positive): “If they were in different clones, this would be suggestive of convergent evolution, that is, two different subclones independently acquiring mutations activating the same pathway, as reported in ALL 18 , pancreatic cancer 19 and renal cancer 20 .”
Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, result): “Consistent with this, leukemia-initiating cells in B-ALLs undergo clonal evolution (Anderson et al., 2011; Notta et al., 2011), though these studies did not test whether the B-ALLs were hierarchically organized according to the cancer stem cell model.”
Cancer stem cells: current status and evolving complexities. (2012, background): “LSCs in acute lymphoblastic leukemia harboring the ETV6-Runx1 translocation were shown to be genetically diverse, exhibiting different degrees of self-renewing and leukemogenic activity in vivo (Anderson et al., 2011).”
Evolution of the cancer stem cell model. (2014, background): “Three independent studies in human B-ALL and T-ALL have provided the essential evidence that subclonal genetic diversity exists within functionally deﬁned L-IC (Anderson et al., 2011; Clappier et al., 2011; Notta et al., 2011).”