Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

By Weimin He, Y. Barak, A. Hevener, P. Olson, D. Liao, Jamie A. Le, M. Nelson, E. Ong, Jerrold M. Olefsky, R. Evans. Proceedings of the National Academy of Sciences of the United States of America, 2003

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Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/039d96cae1360d60a174b17c754300041957705a

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International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006, background): “…is a pivotal actor in adipose tissue differentiation and in maintaining adipocyte specific functions, such as lipid storage in the white adipose tissue and energy dissipation in the brown adipose tissue (Ton-tonoz et al., 1993, 1994b; Rosen et al., 2000; He et al., 2003; Koutnikova et al., 2003).”
Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice (2006, positive): “deposition was performed using established methods (22).”
Developmental origin of fat: tracking obesity to its source. (2007, neutral): “Mature adipocytes in WAT and BAT are also marked by the presence of PPARγ2, markers of terminal differentiation (such as Glut4 and fatty-acid synthase), and insulin-regulated glucose uptake and metabolism (Rosen and MacDougald, 2006).”
Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis (2009, methodology): “Lipoatrophy in mice typically leads to the abnormal deposition of triglyceride in liver and muscles instead, which in turn causes insulin resistance (20).”
Microbial lipases and their industrial applications: a comprehensive review (2020, methodology): “For the determination of organophosphorous pesticides using the lipase hydrolysis a surface acoustic wave impedance biosensor developed [307, 308].”
The Human Obesity Gene Map: The 2005 Update (2006, background): “7) Pparg 3p25 PPARG Loss of peroxisome proliferatoractivated receptor from adipose cells Floxed gene and aP2-driven Cre Reduced adiposity and resistant to dietinduced obesity (513,514)”