Morphogen gradient interpretation

By J. Gurdon, P. Bourillot. Nature, 2001

719 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/036753e9e43bb1bd64047404a004ddbb102ec5b6

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Citations in the corpus

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “, 2007) and tissue patterning during early development (Gurdon and Bourillot, 2001; Saha and Schaffer, 2006; Manjón et al., 2007; Bollenbach et al., 2008) (Fig.”
From cells to organs: building polarized tissue (2008, background): “, and through the sensing of diffusible factors, such as morphogens, chemoattractants and chemorepellant”
Stem cell origin of cancer and differentiation therapy. (2004, background): “Cancer can be viewed as: blocked ontogeny [93,94], a problem of the control of the progenitor cell by its niche [13,73], or a matter of chemical morphogens altering stem cell differentiation [95].”
Auxin acts as a local morphogenetic trigger to specify lateral root founder cells (2008, background): “Although the criteria defining a morphogen in animal systems (25, 26) do not completely fit to plant systems (3, 18), we define a morphogenetic trigger as the factor or signal that induces, through unequal distribution of its activity, acquisition of a new developmental fate in a cell or a group of ”
Building drug delivery into tissue engineering design (2002, background): “For example, it is well known that chemical gradients of factors known as MORPHOGENS induce the formation of structures during developmen”
Developmental constraints, modules, and evolvability (2005, background): “Signaling interactions are of fundamental importance for many patterning processes in development (e.g., Francis-West et al., 1998; Gurdon and Bourillot, 2001), and accordingly, there is considerable opportunity for this mechanism of integration.”
Geometric morphometrics in entomology: Basics and applications (2018, background): “The release of a morphogen from a source forms a morphogen gradient, which leads to the correct spatial arrangement of different cell types (Gurdon & Bourillot 2001).”
Endogenous kynurenines as targets for drug discovery and development (2002, background): “Tissue formation and polarity depend on a morphogenetic gradient, which is probably generated by the sculpting effect of a signal antagonist, rather than an agonis”
Capturing complex 3D tissue physiology in vitro (2006, background): “Because the actions of chemokines and morphogens depend largely on their local gradients relative to the cell rather than absolute amount”