Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response

By R. Mitchell, Hong Liao, J. Chesney, G. Fingerle-Rowson, J. Baugh, J. David, R. Bucala. Proceedings of the National Academy of Sciences of the United States of America, 2001

617 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Immunology

View Paper: https://www.semanticscholar.org/paper/029b0943d2d0db79036a0fb5393c49a1b43fa7b4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Bucala
2. P. Noble
3. T. Roger
4. P. Ward
5. E. Lolis
6. Thierry Calandra

Citations in the corpus

• MIF Signal Transduction Initiated by Binding to CD74 (2003, methodology): “MIF-induced secretion of PGE 2 secretion into medium was measured by specific ELISA (10).”
• CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (2006, methodology): “…production (via cytoplasmic phospholipase A2 and cyclooxygenase-2) (Mitchell et al., 1999; Sampey et al., 2001), regulation of p53 activity (Mitchell et al., 2002), and the activation of additional ERK effectors, such as the Ets family of transcription factors that regulate Toll-like…”
• Novel strategies for the treatment of sepsis (2003, background): “In addition, MIF knockout mice showed protection from p53-induced macrophage apoptosi”
• TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. (2014, neutral): “…HSP90ab1 5 proinflammatory 0.003 (Qin et al., 2011) Tnfsf13b TNF sf13b 4 M1 cytokine* 0.0001 (Martinez et al., 2006) Mif MIF 4 M1 inducer 0.0001 (Mitchell et al., 2002; Yaddanapudi et al., 2013) Spp1 Osteopontin 2 Th1 cytokine 0.02 (Chabas et al., 2001) Anti-inflammatory IL1rn IL1ra 309 M2…”
• Transcriptomic analysis of purified human cortical microglia reveals age-associated changes (2017, background): “In monocytes, heterodimers between CXCR2 and CD74 or between CXCR4 and CD74 induce PI3K–AKT signaling and p53 inhibition, leading to increased survival, proliferation and apoptosis evasion 22 .”
• Macrophage migration inhibitory factor: a regulator of innate immunity (2003, background): “Therefore, the upregulation of expression of TLR4 and sustained cell survival are two mechanisms whereby MIF promotes pro-inflammatory innate immune responses 50, 52 .”