FIZZ1, a novel cysteine‐rich secreted protein associated with pulmonary inflammation, defines a new gene family

By Ilona N. Holcomb, R. Kabakoff, B. Chan, Thad Baker, A. Gurney, W. Henzel, C. Nelson, H. Lowman, Barbara D. Wright, N. Skelton and 5 more. EMBO Journal, 2000

733 citations recorded by the source corpus.

Subfields: Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/027ead5cd4ef9b91aee016ea830631b3bd4822dd

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In Pulmonary and Respiratory Medicine

Citations in the corpus

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms (2015, background): “However, FIZZ1 is abundant in the bronchoalveolar lavage fluid in allergic airway inflammation in the mouse, where it causes vascular inflammation, exhibits chemotactic and fibrogenic properties, induces myofibroblast differentiation, and recruits bone marrow-derived cells [23, 99–102].”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Resistin was identified in 2001 as an adipocyte-specific secreted protein whose expression is down-regulated by anti-diabetic drugs targeting the nuclear receptor peroxisome proliferator-activated receptor (PPAR ) (Holcomb et al. 2000; Kim et al. 2001; Steppan et al. 2001).”
Resistin, an Adipokine with Potent Proinflammatory Properties1 (2005, background): “Resistin was originally described as an adipocyte-derived polypeptide that provided the link between obesity and insulin resistance (2, 3).”
Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. (2004, background): “(117) first described the gene family and its tissue-specific distribution.”
Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ (2001, unknown): “This family is the same as the recently described FIZZ gene family of cysteine-rich secreted proteins (Holcomb et al. 2000), with FIZZ1 equating to REMLα and FIZZ3 to resistin.”
Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “Resistin (ADSF/FIZZ3/XCP1), 10 kDa polypeptide with 114 amino acids in rodents, is identified as an inducer of pulmonary inflammation (Holcomb et al., 2000) and insulin resistance (Steppan et al., 2001).”
The hormone resistin links obesity to diabetes (2001, background): “The unique pattern of cysteines (X 11 -C-X 8 -C-X-C-X 3 -C-X 10 -C-X-C-X-C-X 9 -CC-X 3–6 -END) is conserved in a family of resistin-like molecules including at least three distinct mouse subtype”
Biochemical and functional characterization of three activated macrophage populations (2006, background): “Only the AA-M expressed the marker FIZZ1 described previously, a secreted protein that has been associated with allergic and pulmonary inflammation [7, 28], confirming that FIZZ1 represents a reliable marker for murine AA-M (Fig.”
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (2003, background): “A number of the SPDI proteins have been implicated in a wide range of other biological processes, and further investigation of others is underway (Pennica et al. 1998; Xie et al. 1999; Holcomb et al. 2000).”
Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. (2001, background): “The published sequence of murine resistin is identical to a member (Fizz3) of the recently reported Fizz family of secreted cysteine-rich proteins (1), the index protein of which (Fizz1) was isolated from inflamed lung.”