A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

By D. Lin, A. S. Edwards, J. P. Fawcett, G. Mbamalu, John D. Scott, Tony Pawson. Nature Cell Biology, 2000

818 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/02781332394efc154535aeac056f14d64e4058fa

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Citations in the corpus

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation (2012, neutral): “Par-3 (also known as ASIP) [63] binds to JAM proteins [64-66] and recruits to TJs atypical protein kinase C [67] and Par-6 [68], the three proteins then forming a Planar Cell Polarity (PCP) complex in polarized epithelial cells [69].”
Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo. (2004, background): “The deep local fural., 1996), and homologs of these proteins can complex rowing we observe in par-3 mutants argues against a in vitro (Joberty et al., 2000; Lin et al., 2000).”
Mechanism and role of PDZ domains in signaling complex assembly. (2001, background): “PDZ domains from the mammalian proteins PAR-3 and PAR-6 appear to bind each other in vitro (Lin et al., 2000).”
Tight junctions and cell polarity. (2006, background): “F or p er so na l u se o nl y. Baz: Bazooka with the active form of Cdc42, a Rho GTPase, via its semi-Cdc42/Rac interacting binding (CRIB) domain, and with part of the PDZ domain ( Joberty et al. 2000, Johansson et al. 2000, Lin et al. 2000, Qiu et al. 2000).”
Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice (2007, neutral): “The second complex includes the PDZ protein PAR-3, which binds to atypical protein kinase C (aPKC) (Izumi et al., 1998), and the PDZ protein PAR-6 (Joberty et al., 2000; Lin et al., 2000).”
Developmental cell biology: The cell biology of neurogenesis (2005, background): “and has been implicated in cell polarity and asymmetric divisio”
Rho GTPases: biochemistry and biology. (2005, background): “For example, Par3 inhibits aPKC activity in vitro, and in one report Par6 negatively regulates tight junction formation (Gao et al. 2002, Lin et al. 2000).”
Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. (2005, neutral): “Pawson (University of Toronto) (Lin et al., 2000).”