A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

By Siu Sylvia Lee, Raymond Y. N. Lee, Andrew G. Fraser, R. Kamath, J. Ahringer, Gary Ruvkun. Nature Genetics, 2003

978 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/026eeb7a8f6d67460e5d8ba8a4e02aaba88051c4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. C. Kenyon
2. A. Dillin
3. Brian K. Kennedy
4. T. Blackwell
5. Ronald H. A. Plasterk
6. J. Ahringer
7. F. Simmer
8. R. Kamath

In Molecular Biology

1. C. Kenyon
2. J. Villén
3. A. Dillin
4. Steven P. Gygi
5. J. Ahringer
6. Douglas C. Wallace
7. R. Kamath
8. Toren Finkel

Citations in the corpus

• Extension of chronological life span in yeast by decreased TOR pathway signaling. (2006, background): “Similar transcriptional mechanisms can extend life span in other organisms and are negatively regulated by nutrient signaling ( Lee et al. 2003; Murphy et al. 2003; Giannakou et al. 2004; Hwangbo et al. 2004).”
• Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans (2007, background): “Mitochondrial respiration, like translation, is a major cellular process linked to growth, and reducing respiration in C. elegans extends lifespan (Feng et al., 2001; Dillin et al., 2002; Lee et al., 2003 ).”
• The C. elegans TGF-β Dauer Pathway Regulates Longevity via Insulin Signaling (2007, neutral): “It is also not surprising that RNAi longevity screens did not pick up these genes, despite the use of sterile strains [24–27], because the daf-7 RNAi clone appears to act more weakly than does the mutant allele and might not have met the maximum longevity requirement of these screens (Figure 5).”
• Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. (2008, neutral): “…signaling (IIS) (Friedman and Johnson, 1988; Gottlieb and Ruvkun, 1994; Kenyon et al., 1993; Larsen, 1993), caloric intake (Houthoofd et al., 2002), mitochondrial respiration (Dillin et al., 2002; Lakowski and Hekimi, 1996; Lee et al., 2003), and germline function (Arantes-Oliveira et al., 2002).”
• The plasticity of aging: insights from long-lived mutants. (2005, background): “A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.”
• Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. (2004, background): “…lossof-function screens by gene “knockdowns” (Fraser et al. 2000; Gonczy et al. 2000; Piano et al. 2000, 2002; Hanazawa et al. 2001; Maeda et al. 2001; Zipperlen et al. 2001; Ashrafi et al. 2003; Kamath et al. 2003; Lee et al. 2003; Pothof et al. 2003; Simmer et al. 2003; Vastenhouw et al. 2003).”