Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
By Jia-Yi Li, E. Englund, J. Holton, D. Soulet, Peter Hagell, Andrew Lees, T. Lashley, N. Quinn, S. Rehncrona, A. Björklund and 4 more. Nature Medicine, 2008
1,810 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/022382aa1d9e1f53d091f210c5917ab35d755474
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In Cellular and Molecular Neuroscience
- V. Lee
- Christian Haass
- John Q. Trojanowski
- C. Zuccato
- E. Cattaneo
- M. Valenza
- M. Schwartz
- A. Schapira
In Neurology
- V. Lee
- John Q. Trojanowski
- Christian Haass
- Kelvin C. Luk
- A. Lutz
- K. Winklhofer
- Nicole Exner
- Bin Zhang
Citations in the corpus
- α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. (2011, positive): “Indeed, the initial post-mortem reports on LB and LN in grafted neurons in PD were made in patients who died more than a decade after transplantation (10, 11).”
- BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “Interestingly, recent reports have shown that as early as 14 years after transplantation into the striatum of individuals with PD, grafted nigral neurons are found to have Lewy body-like inclusions that stained positively for -synuclein and ubiquitin and to have reduced immunostaining for DA transpo”
- Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission (2011, background): “…Department of Physiology, Anatomy and Genetics, University of Oxford, UK c Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, UK ⁎ Corresponding author at: Department of Clinica Neurology, University College London, Rowland Hill Fax: +44 20 7472 6829.”