The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

By Fabio Martinon, K. Burns, J. Tschopp. Molecules and Cells, 2002

5,931 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/020f8fd4c7d1519025e367632d436091d6fcf8f8

How researchers see this paper

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In Immunology

1. Shizuo Akira
2. T. Kanneganti
3. J. Tschopp
4. O. Takeuchi
5. Satoshi Uematsu
6. M. Lamkanfi
7. G. Núñez
8. R. Medzhitov

In Molecular Biology

1. T. Kanneganti
2. J. Tschopp
3. G. Núñez
4. M. Lamkanfi
5. Kate Schroder
6. Shizuo Akira
7. V. Dixit
8. E. Latz

Citations in the corpus

• Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration (2007, methodology): “To investigate the mechanism by which low intracellular potassium activates the inflammasome, we employed the in vitro inflammasome activation assay previously described by our group.(4) THP1 cells lysed in a buffer containing 10 mM KCl triggers spontaneous inflammasome assembly and caspase-1 activa”
• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, neutral): “This inflammasome is composed of the adaptor ASC (apoptosis-associated speck-like protein containing a CARD), pro-caspase-1, and an NLR family member, such as Ipaf (Ice protease-activating factor), NALP (NAcht LRR protein) 1, or NALP3/Cryopyrin (226, 231).”
• The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation (2016, background): “NLRP1 NLRP1 was the first cytosolic receptor identified for its ability to form a caspase-1 activating platform (Martinon et al., 2002).”
• Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. (2009, methodology): “Proteolysis of IL-33 in Apoptotic Cell-Free Extracts To explore IL-33 processing further, we used a cell-free system based upon cytosolic extracts derived from LPS-treated monocytic THP-1 cells, where caspase-1, -4, and -5 can be activated by incubating these extracts at 37 C (Yamin et al., 1996; Ma”
• The role of glia in the spinal cord in neuropathic and inflammatory pain. (2015, background): “Rather, IL-1β is synthesised as a larger precursor protein and is cleaved into a mature form; the mechanism behind this has now been elucidated and involves caspase-1, which cleaves IL-1β, and a series of accessory proteins that form a complex known as the inflammasome that provides a platform for t”