Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

By Qin Yang, T. Graham, N. Mody, F. Preitner, O. Peroni, J. Zabolotny, K. Kotani, L. Quadro, B. Kahn. Nature, 2005

2,153 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/020f36889556098ffa530a149ae4a4bd94052502

How researchers see this paper

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In Biochemistry

1. Haiming Cao
2. E. Rosen
3. B. Spiegelman
4. R. Zechner
5. P. Calder
6. I. Djuricić
7. M. Rogero

In Molecular Biology

1. B. Spiegelman
2. E. Rosen
3. Dominic Grün
4. Alexander van Oudenaarden
5. Mitchell A. Lazar
6. A. Hevener
7. R. Barnard
8. Christian K. Roberts

In Physiology

1. Haiming Cao
2. B. Spiegelman
3. E. Rosen
4. Mitchell A. Lazar
5. Herbert Tilg
6. G. Steinberg
7. M. Qatanani
8. R. Zechner

Citations in the corpus

• Adipokines: the missing link between insulin resistance and obesity. (2008, background): “Thereafter, eleated protein RBP-4 plasma levels, synthesized and secreted by dipose tissue, were observed, which suggests an association ith insulin resistance in this mouse model [95].”
• Adipocytes as regulators of energy balance and glucose homeostasis (2006, background): “Because the magnitude of the effect was greater than that predicted by altered glucose flux into adipose tissue alone, an endocrine effect was postulate”
• Gut Microbiota and Immune System Interactions (2020, background): “A major cause of T2DM is impaired insulin action in adipose tissue, skeletal muscle, and the liver [84].”
• Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, positive): “(7) Retinol-binding protein 4 which is linked with insulin resistance((41,42)), although its precise role has been debated((43)).”
• Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “The expression of RBP4 is inversely correlated with that of GLUT4 in adipocytes, and administration of recombinant RBP4 to normal mice induces insulin resistance (Yang et al., 2005).”
• Adipocytokines: mediators linking adipose tissue, inflammation and immunity (2006, background): “Serum retinol-binding protein 4 ( RBP4 ) is another recently characterized adipocytokin”
• Adipose Tissue Heterogeneity: Implication of depot differences in adipose tissue for Obesity Complications (2012, background): “$w aterm ark-text $w aterm ark-text $w aterm ark-text IL-6 interleukin-6 SAA serum amyloid A RBP4 retinol binding protein 4 MCP-1 macrophage chemoattractant protein-1 CRP C-reactive protein GM-CSF granulocyte-macrophage colony stimulating factor TSP-1 thrombospondin 1 References Alberti KG, Eckel RH”
• Inflammatory Mechanisms in the Regulation of Insulin Resistance (2008, background): “Transgenic overexpression of human RBP4 or injection of recombinant RBP4 in normal mice causes IR (68).”
• What We Talk About When We Talk About Fat (2014, positive): “Accordingly, fenretinide was tested for its ability to improve insulin sensitivity and glucose tolerance in obese rodents and was found to be efficacious (Yang et al., 2005).”
• Impact of Obesity and Metabolic Syndrome on Immunity. (2016, background): “Retinol-binding protein 4, an adipokine derived from hypertrophic adipocytes, is also known to impair insulin signaling by reducing phosphatidylinositol-3 kinase signaling in muscle, while concomitantly increasing hepatic gluconeogenic enzyme expression (88, 89).”