Tau is essential to β-amyloid-induced neurotoxicity

By M. Rapoport, Hana N. Dawson, L. Binder, M. Vitek, Adriana Ferreira. Proceedings of the National Academy of Sciences of the United States of America, 2002

770 citations recorded by the source corpus.

Subfields: Biomaterials, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/01893d0f44c89b0c7f64ad609b978e4430eebdba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pharmacology

1. L. Mucke
2. David B. Teplow
3. E. Mandelkow
4. J. Götz
5. D. Selkoe
6. L. Ittner
7. M. Kirkitadze
8. G. Bitan

In Physiology

1. D. Selkoe
2. L. Mucke
3. E. Mandelkow
4. L. Ittner
5. J. Götz
6. David B. Teplow
7. John Hardy
8. G. Bitan

Citations in the corpus

• Post-translational modifications of tau protein: implications for Alzheimer's disease. (2011, positive): “post-translational modification, tau by itself has been reported to mediate Ab-induced neurotoxicity (Rapoport et al., 2002).”
• The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal (2009, background): “While, there is some cell work suggesting that Ab toxicity is dependent on tau expression (Rapoport et al. 2002) and elegant transgenic work showing that tau expression can modulate Ab toxicity (Roberson et al. 2007), we have no idea what the pathway between the two molecules is as yet (Mudher and…”
• Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease (2011, background): “The view that tau plays a mere 'secondary' role in amyloid-β toxicity has been substantially challenged by the observation that tau −/− neurons are protected from amyloid-β-induced cell death in cultur”
• Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies (2002, positive): “In a cell culture model of fibrillar A (cid:1) -induced neuronal injury, hippocampal neurons isolated from transgenic mice expressing either mouse or human tau degenerated, whereas cells from tau knockout animals remained viable (Rapoport et al., 2002).”
• Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease (2018, background): “Indeed, it has already been reported that the suppression or deletion of tau has a profound protective effect against brain damage and neurological deficits (Rapoport et al., 2002; SantaCruz et al., 2005; Roberson et al., 2007; Miao et al., 2010; Shipton et al., 2011; Bi et al., 2017).”