Neural progenitors from human embryonic stem cells

By B. Reubinoff, P. Itsykson, T. Turetsky, M. Pera, Etti Reinhartz, Anna Itzik, T. Ben-Hur. Nature Biotechnology, 2001

1,164 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0092659dd5da6602f1777d2818597420b1dda0d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. G. Keller
2. Kenneth R. Boheler
3. A. Wobus
4. K. Hochedlinger

In Molecular Biology

1. K. Hochedlinger
2. G. Keller
3. G. Daley
4. R. Jaenisch
5. M. Kyba
6. W. Rideout
7. Kenneth R. Boheler
8. A. Wobus

Citations in the corpus

• Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “Neural progenitor cells derived from hES cells (292) may be specifically enriched (69) and directed to differentiate into mature neurons (e.”
• Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, background): “The three CNS cell types can be derived from hES cells using several different protocols (Reubinoff et al. 2001; Zhang et al. 2001).”
• Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient (2009, background): “The injection of pluripotent ESC or ESC-derived precursor cells in rodents leads frequently to the development of teratomas or teratocarcinomas [6,11,12], although the tumorigenic potential of ESC seems to be greatly reduced when cells are predifferentiated in vitro before implantation [7,8,13].”
• Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. (2002, positive): “Similarly, human ES cells have been shown to be highly proliferative and to differentiate in vitro into cells such as neurons ( Reubinoff et al., 2001; Zhang et al., 2001), hematopoietic precursors (Kaufman et al., 2001), and cardiac myocytes (Kehat et al., 2001).”
• Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation (2005, background): “Although hESCs have been directed to differentiate into multipotent neural precursors (Zhang et al., 2001; Reubinoff et al., 2001; Carpenter et al., 2001), their differentiation to a purified neural population has thus far not been demonstrated.”
• Neural induction, the default model and embryonic stem cells (2002, positive): “Similar to the mouse ES cells, most protocols for growth and culturing of human ES cells require FGF2 in the mediu”
• A tumorigenic subpopulation with stem cell properties in melanomas. (2005, background): “medium contains bFGF, which has been used to induce neural differentiation of hESCs and bone marrow–derived stem cells (36, 42, 43).”
• Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury (2005, background): “Although hESCs have been directed to differentiate into multipotent neural precursors (Carpenter et al., 2001; Reubinoff et al., 2001; Zhang et al., 2001; Li et al., 2005), the differentiation protocol that we used here is unique in that it generates a highly purified, specific neural cell type, OPC”