Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

By Ian D. Hickson, Yan Zhao, C. Richardson, Sharon J Green, N. Martin, Alisdair I Orr, P. Reaper, Stephen P. Jackson, N. Curtin, G. Smith. Cancer Research, 2004

1,223 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2a760182845bb6ae7185ff4a7da5fbf0b135c859

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Citations in the corpus

• Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. (2006, background): “KU0055933 (IC50, 13 nmol/L) has been previously validated (12).”
• An ATM-Dependent Transcriptional Silencing Program is Transmitted Through Chromatin in Cis to DNA Double Strand Breaks (2010, background): “Despite potent inhibition of ATM, KU55933 has little effect on the related PIKK kinases, ATR and DNA-PK (Hickson et al., 2004).”
• γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin (2008, background): “Can extensive phosphorylation of H2AX be mediated by other kinases of the PIKK family, such as DNA-PK? Although DNA-PK efficiently phosphorylates H2AX in the absence of ATM, it has been reported that it fails to do so when ATM is inhibited with the help of a specific inhibitor (42).”
• USP10 Regulates p53 Localization and Stability by Deubiquitinating p53 (2010, unknown): “To examine whether USP10 protein becomes USP10 p53 p21 BAX b-actin IR: 0 2 4 24 0 2 4 24 (hrs) Ctrl USP10 - IR LMB IR+LMB IR+Ku55933 USP10 DAPI Merge USP10 MAX C N C N C N C N IR: - + - + HCT116 p53+/+ HCT116 p53-/-”
• ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks (2006, methodology): “To investigate whether ATM and ATR function separately, or in a common pathway, to facilitate IR-induced Chk1 phosphorylation, we used small interfering (si) RNA-mediated ATR depletion and the specific ATM kinase inhibitor, KU55933 (ref”
• Strategies to improve radiotherapy with targeted drugs (2011, background): “1a ), have been shown to sensitize cancer cells and xenografted tumours to radiotherap”