Statistical Analysis of Pseudomonas aeruginosa Biofilm Development: Impact of Mutations in Genes Involved in Twitching Motility, Cell-to-Cell Signaling, and Stationary-Phase Sigma Factor Expression

By A. Heydorn, Bjarne Kjær Ersbøll, J. Kato, M. Hentzer, M. Parsek, T. Tolker-Nielsen, M. Givskov, Søren Molin. Applied and Environmental Microbiology, 2002

314 citations recorded by the source corpus.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ff136ed41b217c9e5ac1fe9e7be0f8b84d4ab9b0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology

1. Søren Molin
2. T. Bjarnsholt
3. M. Givskov
4. George - John Nychas
5. P. Watnick
6. E. Karatan
7. C. Loto
8. M. Parsek

In Genetics

1. T. Bjarnsholt
2. Miguel Cámara
3. E. P. Greenberg
4. Steve Diggle
5. Klaus Winzer
6. P. Watnick
7. M. Givskov
8. E. Karatan

In Molecular Biology

1. T. Bjarnsholt
2. M. Givskov
3. Søren Molin
4. Niels Høiby
5. E. P. Greenberg
6. O. Ciofu
7. P. Watnick
8. E. Karatan

Citations in the corpus

• Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants (2003, background): “The pilHIJK genes, however, encode chemotaxis-related genes (Darzins, 1994) and, although a DpilHIJK mutant is twitching motility deficient (Darzins and Russell, 1997; Heydorn et al., 2002), it has not been shown that this mutant is non-piliated.”
• The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density‐dependency of the quorum sensing hierarchy, regulates rhl‐dependent genes at the onset of stationary phase and can be produced in the absence of LasR (2003, background): “Furthermore, Heydorn et al. (2002) have shown that a flow chamber grown P. aeruginosa rpoS mutant formed densely packed biofilms that were significantly thicker than those of the wild type.”
• Critical review on biofilm methods (2017, methodology): “Therefore, all quantitation by software should be accompanied by statistical analysis to validate the results (Heydorn et al., 2000a, 2002).”
• Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms (2009, result): “aeruginosa biofilm formation, contradictory results have also been reported (131, 257).”
• Quorum Sensing in Staphylococcus aureus Biofilms (2004, background): “Under conditions where biofilms do not develop mushroom-like structures, acyl-HSLs do not appear to influence biofilm structure (21).”
• Antibiotic resistance of bacterial biofilms. (2010, methodology): “This technique has been combined with advanced in silico image analysis to produce three-dimensional images of the biofilm [16–18].”