Levodopa and the progression of Parkinson's disease.
By S. Fahn, D. Oakes, I. Shoulson, K. Kieburtz, A. Rudolph, A. Lang, C. Olanow, C. Tanner, K. Marek. New England Journal of Medicine, 2004
1,827 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/ff01cff1610fde21cba53889a81f864847e0ac31
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In Cellular and Molecular Neuroscience
In Neurology
- Andres M. Lozano
- Eduardo Tolosa
- M. Mouradian
- Kailash Bhatia
- V. Dias
- Jose A. Obeso
- Marwan I. Hariz
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Citations in the corpus
- DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. (2010, background): “One limitation of our investigation that has not been addressed is the potential confounding effect of pharmacotherapy, for example by L-dopa (Fahn et al., 2004).”
- The Role of Oxidative Stress in Parkinson’s Disease (2013, background): “But these concerns were largely laid to rest from the ELLDOPA trial (Earlier versus Late Levodopa), which showed that L-dopa in combination with a peripheral decarboxylase inhibitor is the most effective treatment for PD, with its early use ameliorating the motor symptoms over time [404, 405].”
- The role of DAT-SPECT in movement disorders (2008, background): “F]dopa PET imaging as a surrogate marker of disease progression where 5.7–14.7% of the cases clinically diagnosed as early PD had “scans without evidence of dopaminergic deficit” (SWEEDs).”
- Past, Present, and Future of Parkinson’s Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy (2017, neutral): “As expected, patients on any dosages of levodopa showed significant reductions in UPDRS score when compared with placebo, even 2 weeks after levodopa discontinuation.(175) This finding has been interpreted as evidence against levodopa neurotoxicity because if levodopa were toxic the UPDRS score in t”
- Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up. (2005, background): “It is well known that motor scores obtained after only 12 h of drug abstinence are influenced by the ‘long duration response’ to levodopa and this is a dosedependent effect (Fahn et al., 2004).”