The role of DAT-SPECT in movement disorders

By G. Kägi, Kailash Bhatia, Eduardo Tolosa. Journal of Neurology Neurosurgery & Psychiatry, 2008

314 citations recorded by the source corpus.

Dopamine transporter (DAT) imaging is a sensitive method to detect presynaptic dopamine neuronal dysfunction, which is a hallmark of neurodegenerative parkinsonism. DAT imaging can therefore assist the differentiation between conditions with and without presynaptic dopaminergic deficit. Diagnosis of Parkinson disease or tremor disorders can be achieved with high degrees of accuracy in cases with full expression of classical clinical features; however, diagnosis can be difficult, since there is a substantial clinical overlap especially in monosymptomatic tremor (dystonic tremor, essential tremor, Parkinson tremor). The use of DAT-SPECT can prove or excludes with high sensitivity nigrostriatal dysfunction in those cases and facilitates early and accurate diagnosis. Furthermore, a normal DAT-SPECT is helpful in supporting a diagnosis of drug-induced-, psychogenic- and vascular parkinsonism by excluding underlying true nigrostriatal dysfunction. This review addresses the value of DAT-SPECT and its impact on diagnostic accuracy in movement disorders presenting with tremor and/or parkinsonism.

Subfields: Neurology

View Paper: https://www.semanticscholar.org/paper/c2b9de1ee694c5337bae457d58dc0d9414a94ad0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

Citations in the corpus

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. (2018, background): “DaT scanning is useful to distinguish PD from other causes of parkinsonism that do not affect dopaminergic nigrostriatal neurons (e.g., essential tremor, drug-induced and vascular parkinsonism) but not from parkinsonism from other degenerative disorders (e.g., MSA, PSP, CBD) (Kagi et al. 2010).”