Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset.

By N. Wexler, J. Lorimer, J. Porter, F. Gomez, C. Moskowitz, Edith Shackell, K. Marder, G. Penchaszadeh, S. Roberts, J. Gayán and 48 more. Proceedings of the National Academy of Sciences of the United States of America, 2004

771 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fda4fdf677d2c9ee66b0f5aff45d9a00e9f4d5c1

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In Cellular and Molecular Neuroscience

1. C. Zuccato
2. E. Cattaneo
3. M. Valenza
4. Brent R. Stockwell
5. Tal Hirschhorn

In Molecular Biology

1. Zena Werb
2. M. Egeblad
3. Andrew J. Ewald
4. Sarah J. Tabrizi
5. Christopher A. Ross
6. M. Valenza
7. E. Cattaneo
8. C. Zuccato

Citations in the corpus

• Huntington disease: natural history, biomarkers and prospects for therapeutics (2014, background): “The systematic study of HD, leading to the identification of the HTT gene, began with the seminal and continuing study of the condition in a very large pedigree in Venezuela.(15,16) Subsequently, HD research has benefited from several longitudinal single-centre and multicentre studies.”
• Molecular mechanisms and potential therapeutical targets in Huntington's disease. (2010, background): “This CAG repeat number only explains 40–50% of the variance in the age of onset and the remaining is influenced by environmental and genetic factors as, for example, paternal inheritance (12, 77, 458, 634).”
• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, background): “Huntington’s disease (Wexler et al., 2004) and sickle cell anemia (Sebastiani et al.”