Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees

By P. Khaitovich, Ines Hellmann, Wolfgang Enard, Katja Nowick, M. Leinweber, Henriette Franz, G. Weiss, M. Lachmann, Svante Pääbo. Science, 2005

609 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fd97b76fffbb6e296bbf7ad803d41601deea5ec7

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Citations in the corpus

A census of human transcription factors: function, expression and evolution (2009, background): “At the level of gene expression, comparisons of primate transcriptomes showed that, whereas most genes have maintained similar profiles, a small subset of genes — particularly TFs — display significantly changed expression levels in the human lineag”
The model organism as a system: integrating 'omics' data sets (2006, positive): “A follow-up study that lends support to this idea integrated genomics and transcriptomics data, and identified a trend towards increased protein-coding changes between humans and chimpanzees in brain-specific genes relative to other tissue”
The evolution of sex-biased genes and sex-biased gene expression (2007, background): “Comparison of the human and chimpanzee genomes has shown that the rapid evolution of male-biased genes also extends to primate lineages: genes expressed in testis, especially those that are specific to testis, are the fastest evolving of all genes for which tissue-based expression profile has been i”
The evolutionary significance of cis-regulatory mutations (2007, background): “Subsequent microrray studies have found that ∼10% of genes examined differ in brain expression between humans and chimpanzee”
Brain Plasticity and Human Evolution (2017, neutral): “Several studies have shown that among the genes that are differentially expressed in the human neocortex, a greater number show an increase in expression than show a decrease (Preuss et al. 2004, Khaitovich et al. 2005, Vallender et al. 2008; but see Uddin et al. 2004, Babbitt et al. 2010).”