The evolutionary significance of cis-regulatory mutations

By Gregory A. Wray. Nature reviews genetics, 2007

1,564 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f863b0bc0f742565dd93f9549d62faab4927ec5a

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In Genetics

Citations in the corpus

DNA transposons and the evolution of eukaryotic genomes. (2007, background): “The generation of new alleles and the creation of novel regulatory circuits are major forces underlying the diversification of species (14, 24, 104, 196).”
Enhancer Evolution across 20 Mammalian Species (2015, background): “Given that most phenotypic differences are hypothesized to largely result from regulatory differences between mammals, it is of profound importance to understand the mechanisms driving enhancer evolution (Villar et al., 2014; Wray, 2007).”
The Loci of Evolution: How Predictable is Genetic Evolution? (2008, background): “…(see for example Jacob and Monod 1961; Wallace 1963; Zuckerkandl 1963; Britten and Davidson 1969, 1971; King and Wilson 1975; Wilson 1975; Jacob 1977; Raff and Kaufman 1983; Carroll 1995; Gerhart and Kirschner 1997; Akam 1998; Stern 2000; Davidson 2001; Wray et al. 2003; Davidson 2006; Wray 2007).”
Gene duplication and the origins of morphological complexity in pancrustacean eyes, a genomic approach (2010, background): “The more pleiotropic developmental genes could rely more heavily on modifications in the protein and cis-regulatory sequences, rather than on gene duplication for diversifying function [57].”
A Comparative Encyclopedia of DNA Elements in the Mouse Genome (2014, background): “Recent studies have revealed divergent DNA binding patterns for a limited number of transcription factors across multiple related mammals 3–6, 7,8 , suggesting potentially wide-ranging differences in cellular functions and regulatory mechanisms 9,10 .”
Bridging the gap between the genotype and the phenotype: linking genetic variation, selection and adaptation in fishes (2008, background): “In fact, there is some debate about the relative importance of regulatory and protein categories in phenotypic evolution (Hoekstra and Coyne 2007; Wray 2007).”
Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system (2015, background): “mutations can contribute to gene network evolution (19), but that as predicted, such 113 mutations bear severe pleiotropic costs (20, 21).”
The QTN Program and the Alleles That Matter for Evolution: All That’s Gold Does Not Glitter (2011, background): “…differences, aside from effect size, among QTNs from different categories of molecular function, but I will not treat these here as they have been reviewed elsewhere at length (Mitchison 1997; Stern 2000; Ohta 2003; Wray 2007; Carroll 2008; Lynch and Wagner 2008; Stern and Orgogozo 2008, 2009).”
Rare and Common Variants: Twenty arguments (2011, background): “It remains to be seen whether the same is true of regulatory polymorphism”
Molecular mechanisms of heavy metal tolerance and evolution in invertebrates (2009, background): “Mutations responsible for variation in transcriptional regulation of a certain gene can be located in different sites of a genome (Wray et al., 2003; Wittkopp, 2005; Wray, 2007).”
Evo‐Devo and an Expanding Evolutionary Synthesis (2008, neutral): “Regulatory sequences have different properties and are under different constraints than coding sequences (Wray, 2007).”
Whole-genome duplication in teleost fishes and its evolutionary consequences (2014, background): “It is still lively debated whether changes in coding- or non-coding sequences are more relevant to the evolution of genes and new traits (Carroll 2000; Hoekstra and Coyne 2007; Wray 2007; Lynch and Wagner 2008; Wittkopp and Kalay 2012).”
Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence (2011, background): “Compared to promoters, enhancers tend to be more variable between species; they are the type of CRE that is most often thought to be responsible for cis -regulatory divergenc”
THE LOCUS OF EVOLUTION: EVO DEVO AND THE GENETICS OF ADAPTATION (2007, background): “Contrary to our view, Wray (2007) concludes that there is ample empirical evidence to support the claim that cis-regulatory mutations are more important than structural mutations in phenotypic evolution.”