Cellular senescence: from physiology to pathology

By D. Muñoz‐Espín, Manuel Serrano. Nature reviews. Molecular cell biology, 2014

2,510 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/fd8bd8d43471858fd55a8819516dd95c7be038cd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Jesús Gil
2. J. Campisi

In Molecular Biology

1. Jesús Gil
2. J. Campisi
3. M. Demaria
4. Domhnall McHugh
5. Manuel Serrano
6. P. Jat
7. R. Kumari
8. Masashi Narita

In Physiology

1. J. Campisi
2. Jesús Gil
3. M. Demaria
4. Manuel Serrano
5. Domhnall McHugh
6. P. Jat
7. R. Kumari
8. M. Collado

Citations in the corpus

• Measuring biological aging in humans: A quest (2019, background): “Cellular senescence is a stress response mechanism characterized by replication arrest and complex changes in morphology, chromatin organization, secretome, and expression of typical protein biomarkers (Muñoz-Espín & Serrano, 2014; Rodier & Campisi, 2011).”
• ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases (2016, background): “When the senescent cell program is inefficiently developed, as it occurs during the aging, the secretoma causes detrimental effects [151–153, 167, 168, 199].”
• Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “Senescence, a cellular response that limits the proliferation of aged or damaged cells (Muñoz-Espín et al., 2013; Muñoz-Espín and Serrano, 2014), belongs to the antagonistic class (Fig.”
• TGF-β1 Signaling and Tissue Fibrosis. (2018, background): “TGF-b signaling through Smad-dependent and -independent pathways intersects with many senescence and apoptotic pathways (Munoz-Espin et al. 2013; Munoz-Espin and Serrano 2014).”
• TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019 (2019, background): “Cellular senescence protects from malignant transdifferentiation and plays crucial roles in aging and wound healing [248].”
• Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence (2017, neutral): “1d)1, 33, 34.”
• Cellular Senescence: Defining a Path Forward. (2019, background): “In most studies, senescence is assessed in ex vivo cultures or fresh samples by SA-b -gal staining or indirect markers in formalin-fixed tissues (Haugstetter et al., 2010; He and Sharp-less, 2017; Kuilman and Peeper, 2009; Mun˜oz-Espı´n and Serrano, 2014; Serrano et al., 1997).”
• Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL (2016, neutral): “Cellular stress induced by the DNA damage response is a central mechanism that drives senescence in aging and age-related diseases 2,3,12 .”
• Mechanisms and functions of cellular senescence. (2018, neutral): “However, a wealth of data has demonstrated that senescent cells can influence disease and aging, as well as normal tissue homeostasis (5).”